Structure of PDB 6bhi Chain A Binding Site BS01
Receptor Information
>6bhi Chain A (length=215) Species:
9606
(Homo sapiens) [
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GELSKDGDLIVSMRILGKKRTKTWHKGTLIAIQTVGPGKKYKVKFDNKGK
SLLSGNHIAYDYHPPDKLYVGSRVVAKYKDGNQVWLYAGIVAETPNVKNK
LRFLIFFDDGYASYVTQSELYPICRPLKKTWEDIEDISCRDFIEEYVTAY
PNRPMVLLKSGQLIKTEAEGTWWKSRVEEVDGSLVRILFLDDKRCEWIYR
GSTRLEPMFSMKTSS
Ligand information
>6bhi Chain B (length=9) Species:
9606
(Homo sapiens) [
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KSTGGKAPR
Receptor-Ligand Complex Structure
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PDB
6bhi
H3K14ac is linked to methylation of H3K9 by the triple Tudor domain of SETDB1.
Resolution
1.4 Å
Binding residue
(original residue number in PDB)
Y268 Y277 F296 G300 Y301 A302 F332 E357 E359 E386 I388 Y389 S392 R394 S404 S405
Binding residue
(residue number reindexed from 1)
Y78 Y87 F106 G110 Y111 A112 F142 E167 E169 E196 I198 Y199 S202 R204 S214 S215
Enzymatic activity
Enzyme Commision number
2.1.1.366
: [histone H3]-N(6),N(6)-dimethyl-lysine(9) N-methyltransferase.
External links
PDB
RCSB:6bhi
,
PDBe:6bhi
,
PDBj:6bhi
PDBsum
6bhi
PubMed
29234025
UniProt
Q15047
|SETB1_HUMAN Histone-lysine N-methyltransferase SETDB1 (Gene Name=SETDB1)
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