Structure of PDB 6bhh Chain A Binding Site BS01
Receptor Information
>6bhh Chain A (length=210) Species:
9606
(Homo sapiens) [
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GELSKDGDLIVSMRILGKKRTKTWHKGTLIAIQTVGPGKKYKVKFDNKGK
SLLSGNHIAYDYHPPADKLYVGSRVVAKYKQVWLYAGIVAETPNVKNKLR
FLIFFDDGYASYVTQSELYPICRPLKKTWEDIEDISCRDFIEEYVTAYPN
RPMVLLKSGQLIKTEAEGTWWKSRVEEVDGSLVRILFLDDKRCEWIYRGS
TRLEPMFSMK
Ligand information
>6bhh Chain B (length=10) Species:
9606
(Homo sapiens) [
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KSTGGKAPRK
Receptor-Ligand Complex Structure
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PDB
6bhh
H3K14ac is linked to methylation of H3K9 by the triple Tudor domain of SETDB1.
Resolution
1.85 Å
Binding residue
(original residue number in PDB)
F296 G300 Y301 A302 F332 E357 I388 Y389 S392 R394
Binding residue
(residue number reindexed from 1)
F104 G108 Y109 A110 F140 E165 I196 Y197 S200 R202
Enzymatic activity
Enzyme Commision number
2.1.1.366
: [histone H3]-N(6),N(6)-dimethyl-lysine(9) N-methyltransferase.
External links
PDB
RCSB:6bhh
,
PDBe:6bhh
,
PDBj:6bhh
PDBsum
6bhh
PubMed
29234025
UniProt
Q15047
|SETB1_HUMAN Histone-lysine N-methyltransferase SETDB1 (Gene Name=SETDB1)
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