Structure of PDB 6bhg Chain A Binding Site BS01
Receptor Information
>6bhg Chain A (length=215) Species:
9606
(Homo sapiens) [
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GGELSKDGDLIVSMRILGKKRTKTWHKGTLIAIQTVGPGKKYKVKFDNKG
KSLLSGNHIAYDYHPPADKLYVGSRVVAKYKDVWLYAGIVAETPNVKNKL
RFLIFFDDGYASYVTQSELYPICRPLKKTWEDIEDISCRDFIEEYVTAYP
NRPMVLLKSGQLIKTEWEGTWWKSRVEEVDGSLVRILFLDDKRCEWIYRG
STRLEPMFSMKTSSA
Ligand information
>6bhg Chain B (length=9) Species:
9606
(Homo sapiens) [
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STGGKAPRK
Receptor-Ligand Complex Structure
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PDB
6bhg
H3K14ac is linked to methylation of H3K9 by the triple Tudor domain of SETDB1.
Resolution
1.45 Å
Binding residue
(original residue number in PDB)
F296 G300 A302 F332 E357 W358 E386 I388 Y389 S392 T393 R394
Binding residue
(residue number reindexed from 1)
F105 G109 A111 F141 E166 W167 E195 I197 Y198 S201 T202 R203
Enzymatic activity
Enzyme Commision number
2.1.1.366
: [histone H3]-N(6),N(6)-dimethyl-lysine(9) N-methyltransferase.
External links
PDB
RCSB:6bhg
,
PDBe:6bhg
,
PDBj:6bhg
PDBsum
6bhg
PubMed
29234025
UniProt
Q15047
|SETB1_HUMAN Histone-lysine N-methyltransferase SETDB1 (Gene Name=SETDB1)
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