Structure of PDB 6bfo Chain A Binding Site BS01

Receptor Information
>6bfo Chain A (length=145) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SGISLDNSYKMDYPEMGLCIIINNKNFHKSTGMTSRSGTDVDAANLRETF
RNLKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLSHGEEGIIF
GTNGPVDLKKITNFFRGDRCRSLTGKPKLFIIQACRGTELDCGIE
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6bfo Modifications to a common phosphorylation network provide individualized control in caspases.
Resolution1.54 Å
Binding residue
(original residue number in PDB)		R64 C163
Binding residue
(residue number reindexed from 1)		R36 C135
Enzymatic activity
Catalytic site (original residue number in PDB) T62 S63 H121 G122 C163
Catalytic site (residue number reindexed from 1) T34 S35 H93 G94 C135
Enzyme Commision number 3.4.22.56: caspase-3.
Gene Ontology
Molecular Function
GO:0004197 cysteine-type endopeptidase activity
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:6bfo, PDBe:6bfo, PDBj:6bfo
PDBsum6bfo
PubMed29414778
UniProtP42574|CASP3_HUMAN Caspase-3 (Gene Name=CASP3)

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