Structure of PDB 6bdn Chain A Binding Site BS01

Receptor Information

>6bdn Chain A (length=307) Species: 9606 (Homo sapiens)

DPEIADLFYKDDPEELFIGLHEIGHGSFGAVYFATNAHTSEVVAIKKMSY
SGKQTHEKWQDILKEVKFLRQLKHPNTIEYKGCYLKEHTAWLVMEYCLGS
ASDLLEVHKKPLQEVEIAAITHGALHGLAYLHSHALIHRDIKAGNILLTE
PGQVKLADFGSASMASPANSFVGTPYWMAPEVILAMDEGQYDGKVDIWSL
GITCIELAERKPPLFNMNAMSALYHIAQNDSPTLQSNEWTDSFRRFVDYC
LQKIPQERPTSAELLRHDFVRRDRPLRVLIDLIQRTKDAVRELDNLQYRK
MKKILFQ

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 6bdn Chain A Residue 403

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6bdn Crystal structure of human TAO3 kinase binding ADP
• Resolution: 1.5 Å
• Binding residue (original residue number in PDB): N152 D165
• Binding residue (residue number reindexed from 1): N145 D158
• Annotation score: 1

Enzymatic activity

• Catalytic site (original residue number in PDB): D147 K149 N152 D165 P174 T181
• Catalytic site (residue number reindexed from 1): D140 K142 N145 D158 P167 T174
• Enzyme Commision number: 2.7.11.1: non-specific serine/threonine protein kinase.

Gene Ontology

Molecular Function

• GO:0004672 protein kinase activity
• GO:0005524 ATP binding

Biological Process

• GO:0006468 protein phosphorylation

External links

• PDB: RCSB:6bdn, PDBe:6bdn, PDBj:6bdn
• PDBsum: 6bdn
• UniProt: Q9H2K8|TAOK3_HUMAN Serine/threonine-protein kinase TAO3 (Gene Name=TAOK3)