Structure of PDB 6bd4 Chain A Binding Site BS01

Receptor Information

>6bd4 Chain A (length=379) Species: 1501,9606

CHSVGTNSDQYIWVKRSLNCVLKCGYDAGLYSRSAKEFTDIWMAVWASLC
FISTAFTVLTFLIDSSRFSYPERPIIFLSMCYNIYSIAYIVRLTVGRERI
SCDFEEAAEPVLIQEGLKNTGCAIIFLLLYFFGMASSIWWVILTLTWFLA
AGLKWGHEAIEMHSSYFHIAAWAIPAVKTIVILIMRLVDADELTGLCYVG
NQNLDALTGFVVAPLFTYLVIGTLFIAAGLVALFKIRSNMKKYTCTVCGY
IYNPEDGDPDNGVNPGTDFKDIPDDWVCPLCGVGKDQFEEVEEDKLERLM
VKIGVFSVLYTVPATIVIACYFYEISNWALFRYSADDSNMAVEMLKIFMS
LLVGITSGMWIWSAKTLHTWQKFYNRLVN

Ligand information

• Ligand ID: ZN
• InChI: InChI=1S/Zn/q+2
• InChIKey: PTFCDOFLOPIGGS-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Zn++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Zn+2]
• Formula: Zn
• Name: ZINC ION
• ChEMBL: CHEMBL1236970
• DrugBank: DB14532
• PDB chain: 6bd4 Chain A Residue 1101

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6bd4 Crystal structure of the Frizzled 4 receptor in a ligand-free state.
• Resolution: 2.4 Å
• Binding residue (original residue number in PDB): C1006 C1009 C1039
• Binding residue (residue number reindexed from 1): C245 C248 C278
• Annotation score: 4

Gene Ontology

Molecular Function

• GO:0004888 transmembrane signaling receptor activity
• GO:0005506 iron ion binding
• GO:0009055 electron transfer activity
• GO:0042813 Wnt receptor activity
• GO:0046872 metal ion binding

Biological Process

• GO:0007166 cell surface receptor signaling pathway
• GO:0016055 Wnt signaling pathway
• GO:0043448 alkane catabolic process

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:6bd4, PDBe:6bd4, PDBj:6bd4
• PDBsum: 6bd4
• PubMed: 30135577
• UniProt: P00268|RUBR_CLOPA Rubredoxin;
  Q9ULV1|FZD4_HUMAN Frizzled-4 (Gene Name=FZD4)