Structure of PDB 6ax7 Chain A Binding Site BS01

Receptor Information
>6ax7 Chain A (length=195) Species: 212035 (Acanthamoeba polyphaga mimivirus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EVTLYDLPTRKEEWEKKYLHPEFLSHLQNFKDFDYTEICNDVYSFPLFTP
AFCKEVIEVMDKANLWSTQDTQLYEVGLDKQWHYVVFNYVAPFVRHLYNN
YKTKDINLAFVVKYDMERQSELAPHHDSSTYTLNIALNEYGKEYTAGGCE
FIRHKFIWQGQKVGYATIHAGKLLAYHRALPITSGKRYILVSFVN
Ligand information
Ligand IDFE2
InChIInChI=1S/Fe/q+2
InChIKeyCWYNVVGOOAEACU-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Fe+2]
CACTVS 3.341[Fe++]
FormulaFe
NameFE (II) ION
ChEMBL
DrugBankDB14510
ZINC
PDB chain6ax7 Chain A Residue 901 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6ax7 Pro-metastatic collagen lysyl hydroxylase dimer assemblies stabilized by Fe2+-binding.
Resolution2.002 Å
Binding residue
(original residue number in PDB)		H825 D827 H877
Binding residue
(residue number reindexed from 1)		H125 D127 H177
Annotation score1
Enzymatic activity
Enzyme Commision number 1.14.11.4: procollagen-lysine 5-dioxygenase.
2.4.1.-
Gene Ontology
Molecular Function
GO:0005506 iron ion binding
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0031418 L-ascorbic acid binding

View graph for
Molecular Function
External links
PDB RCSB:6ax7, PDBe:6ax7, PDBj:6ax7
PDBsum6ax7
PubMed29410444
UniProtQ5UQC3|PLOD_MIMIV Procollagen lysyl hydroxylase and glycosyltransferase (Gene Name=MIMI_L230)

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