Structure of PDB 6ax4 Chain A Binding Site BS01
Receptor Information
>6ax4 Chain A (length=221) Species:
9606
(Homo sapiens) [
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HLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYG
LGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSL
MKKITLLKYFRNYMSEHLLKAGANITPRDELARLPYLRTWFRTRSAIILH
LSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCK
ELASRLRYARTMVDKLLSSRS
Ligand information
>6ax4 Chain C (length=5) Species:
32630
(synthetic construct) [
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PLHST
Receptor-Ligand Complex Structure
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PDB
6ax4
Histidine N( tau )-cyclized macrocycles as a new genre of polo-like kinase 1 polo-box domain-binding inhibitors.
Resolution
1.45 Å
Binding residue
(original residue number in PDB)
K413 W414 V415 D416 Y417 L478 Y481 Y485 L490 L491 R516 F535 H538 K540
Binding residue
(residue number reindexed from 1)
K41 W42 V43 D44 Y45 L106 Y109 Y113 L118 L119 R142 F161 H164 K166
Enzymatic activity
Enzyme Commision number
2.7.11.21
: polo kinase.
External links
PDB
RCSB:6ax4
,
PDBe:6ax4
,
PDBj:6ax4
PDBsum
6ax4
PubMed
30174151
UniProt
P53350
|PLK1_HUMAN Serine/threonine-protein kinase PLK1 (Gene Name=PLK1)
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