Structure of PDB 6avs Chain A Binding Site BS01

Receptor Information

>6avs Chain A (length=236) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

GGTVPRLHRPSLQHFREQFLVPGRPVILKGVADHWPCMQKWSLEYIQEIA
GCRTVPVEVGSRYTDEEWSQTLMTVNEFISKYIVNEPRDVGYLAQHQLFD
QIPELKQDISIPDYCSLGDGEEEEITINAWFGPQGTISPLHQDPQQNFLV
QVMGRKYIRLYSPQESGALYPHDTHLLHNTSQVDVENPDLEKFPKFAKAP
FLSCILSPGEILFIPVKYWHYVRALDLSFSVSFWWS

Ligand information

Ligand ID

InChI

InChI=1S/Zn/q+2

InChIKey

PTFCDOFLOPIGGS-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Zn++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Zn+2]

Formula

Name

ZINC ION

PDB chain

6avs Chain A Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	6avs Specific Recognition of Arginine Methylated Histone Tails by JMJD5 and JMJD7.
Resolution	2.02 Å
Binding residue (original residue number in PDB)	H321 D323 H400
Binding residue (residue number reindexed from 1)	H141 D143 H220
Annotation score	1

Enzymatic activity

Enzyme Commision number

1.14.11.73: [protein]-arginine 3-hydroxylase.
3.4.-.-

External links

PDB	RCSB:6avs, PDBe:6avs, PDBj:6avs
PDBsum	6avs
PubMed	29459673
UniProt	Q8N371\|KDM8_HUMAN Bifunctional peptidase and arginyl-hydroxylase JMJD5 (Gene Name=KDM8)

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