Structure of PDB 6as6 Chain A Binding Site BS01

Receptor Information
>6as6 Chain A (length=712) Species: 1773 (Mycobacterium tuberculosis) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TDRVSVGNLRIARVLYDFVNNEALPGTDIDPDSFWAGVDKVVADLTPQNQ
ALLNARDELQAQIDKWHRRRVIEPIDMDAYRQFLTEIGYLLPEPDDFTIT
TSGVDAEITTTAGPQLVVPVLNARFALNAANARWGSLYDALYGTDVIPET
DGAEKGPTYNKVRGDKVIAYARKFLDDSVPLSSGSFGDATGFTVQDGQLV
VALPDKSTGLANPGQFAGYTGAAESPTSVLLINHGLHIEILIDPESQVGT
TDRAGVKDVILESAITTIMDFEDSVAAVDAADKVLGYRNWLGLNKGDLAA
RVLNRDRNYTAPGGGQFTLPGRSLMFVRNVGHLMTNDAIVDTDGSEVFEG
IMDALFTGLIAIHGLKASDGPLINSRTGSIYIVKPKMHGPAEVAFTCELF
SRVEDVLGLPQNTMKIGIMDEERRTTVNLKACIKAAADRVVFINTGFLDR
TGDEIHTSMEAGPMVRKGTMKSQPWILAYEDHNVDAGLAAGFSGRAQVGK
GMWTMTELMADMVETKIAQPRAGASTAWVPSPTAATLHALHYHQVDVAAV
QQGLAGKRRATIEQLLTIPLAKELAWAPDEIREEVDNNCQSILGYVVRWV
DQGVGASKVPDIHDVALMEDRATLRISSQLLANWLRHGVITSADVRASLE
RMAPLVDRQNDVAYRPMAPNFDDSIAFLAAQELILSGAQQPNGYTEPILH
RRRREFKARAAE
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain6as6 Chain A Residue 801 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6as6 Anion-pi Interactions in Computer-Aided Drug Design: Modeling the Inhibition of Malate Synthase by Phenyl-Diketo Acids.
Resolution1.4 Å
Binding residue
(original residue number in PDB)		E434 D462
Binding residue
(residue number reindexed from 1)		E421 D449
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) D271 E273 R339 E434 D462 D633
Catalytic site (residue number reindexed from 1) D270 E272 R328 E421 D449 D620
Enzyme Commision number 2.3.3.9: malate synthase.
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0001968 fibronectin binding
GO:0003824 catalytic activity
GO:0004474 malate synthase activity
GO:0005515 protein binding
GO:0005518 collagen binding
GO:0016740 transferase activity
GO:0042803 protein homodimerization activity
GO:0043236 laminin binding
GO:0046810 host cell extracellular matrix binding
GO:0046872 metal ion binding
GO:0120225 coenzyme A binding
Biological Process
GO:0006097 glyoxylate cycle
GO:0006099 tricarboxylic acid cycle
GO:0009436 glyoxylate catabolic process
GO:0015936 coenzyme A metabolic process
GO:0044406 adhesion of symbiont to host
Cellular Component
GO:0005576 extracellular region
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0009274 peptidoglycan-based cell wall
GO:0009986 cell surface
GO:0042603 capsule

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6as6, PDBe:6as6, PDBj:6as6
PDBsum6as6
PubMed30137983
UniProtP9WK17|MASZ_MYCTU Malate synthase G (Gene Name=glcB)

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