Structure of PDB 6am0 Chain A Binding Site BS01

Receptor Information
>6am0 Chain A (length=260) Species: 284590 (Kluyveromyces lactis NRRL Y-1140) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SLPLLRPFETVSLENAVEDLVVRFILNVPPEDLSTVERVLFHFEEASWFY
TDFVKLMNPYLPNLSIKSFSKIVIDICPLIWNWDITPENALVKFSNYKKT
IPVRGAAIFNDSLSKILLLRGINSKHWSFPRGKIGKDEDDVACCIREVKE
QTGFDLTGFIDADQYVERNMNGKNFKIFLVKGVPEDFEFKPEHKNEIQAI
EWKDFKKLSKAITKNEAKVFLVNSMIRPLSLYVKNEKRAKDENKLKLYAE
EHLKSILGLN
Ligand information
>6am0 Chain C (length=23) Species: 284590 (Kluyveromyces lactis NRRL Y-1140) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
KCYAGATFATEAPQVTTLPKPSF
Receptor-Ligand Complex Structure
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PDB6am0 Structure of the activated Edc1-Dcp1-Dcp2-Edc3 mRNA decapping complex with substrate analog poised for catalysis.
Resolution2.84 Å
Binding residue
(original residue number in PDB)		P30 E32 D33 R39 F42 Y98 T101 I102 I135 G136 K137 E139
Binding residue
(residue number reindexed from 1)		P29 E31 D32 R38 F41 Y97 T100 I101 I134 G135 K136 E138
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0016787 hydrolase activity
GO:0030145 manganese ion binding
GO:0140933 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity
Biological Process
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA

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Molecular Function
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Biological Process
External links
PDB RCSB:6am0, PDBe:6am0, PDBj:6am0
PDBsum6am0
PubMed29559651
UniProtQ6CIU1

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