Structure of PDB 6alp Chain A Binding Site BS01

Receptor Information

>6alp Chain A (length=338) Species: 1960 (Streptomyces vinaceus)

VRPWSEFRLTPAEAAAAAALAARCAQRYDETDGPEFLLDAPVIAHELPRR
LRTFMARARLDAWPHALVVRGNPVDDAALGSTPVHWRTARTPGSRPLSFL
LMLYAGLLGDVFGWATQQDGRVVTDVLPIKGGEHTLVSSSSRQELGWHTE
DAFSPYRADYVGLLSLRNPDGVATTLAGVPLDDLDERTLDVLFQERFLIR
PDDSHLQVNNSTAQQGRVEFEGIAQAADRPEPVAILTGHRAAPHLRVDGD
FSAPAEGDEEAAAALGTLRKLIDASLYELVLDQGDVAFIDNRRAVHGRRA
FQPRYDGRDRWLKRINITRDLHRSRKAWAGDSRVLGQR

Ligand information

• Ligand ID: FE2
• InChI: InChI=1S/Fe/q+2
• InChIKey: CWYNVVGOOAEACU-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Fe+2]
  CACTVS 3.341: [Fe++]
• Formula: Fe
• Name: FE (II) ION
• DrugBank: DB14510
• PDB chain: 6alp Chain A Residue 401

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6alp Visualizing the Reaction Cycle in an Iron(II)- and 2-(Oxo)-glutarate-Dependent Hydroxylase.
• Resolution: 1.99 Å
• Binding residue (original residue number in PDB): H168 E170 H316
• Binding residue (residue number reindexed from 1): H148 E150 H296
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 1.14.11.41: L-arginine hydroxylase.

Gene Ontology

Molecular Function

• GO:0005506 iron ion binding
• GO:0016491 oxidoreductase activity
• GO:0016706 2-oxoglutarate-dependent dioxygenase activity
• GO:0046872 metal ion binding
• GO:0102525 2-oxoglutarate, L-arginine oxygenase (succinate-forming) activity

Biological Process

• GO:0017000 antibiotic biosynthetic process

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:6alp, PDBe:6alp, PDBj:6alp
• PDBsum: 6alp
• PubMed: 28823155
• UniProt: Q6WZB0|ARGHX_STRVI Alpha-ketoglutarate-dependent L-arginine hydroxylase (Gene Name=vioC)