Structure of PDB 6a8g Chain A Binding Site BS01

Receptor Information
>6a8g Chain A (length=245) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IVGGEFTEVENQPWFAAIYQKNKSPPSFKCGGSLISPCWVASAAHCFIQL
PKKENYVVYLGQSKESSYNPGEMKFEVEQLILHEYYREDSLAYHNDIALL
KIRTSTGQCAQPSRSIQTIALPPRFTDAPFGSDCEITGFGKESESDYLYP
KNLKMSVVKLVSHEQCMQPHYYGSEINYKMLCAADPEWKTDSCKGDSGGP
LICNIEGRPTLSGIVSWGRGCAEKNKPGVYTRVSHFLDWIQSHIG
Ligand information
>6a8g Chain P (length=10) Species: 279974 (Phage display vector pTDisp) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
CPAYSRYIGC
Receptor-Ligand Complex Structure
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PDB6a8g Suppression of Tumor Growth and Metastases by Targeted Intervention in Urokinase Activity with Cyclic Peptides.
Resolution2.53 Å
Binding residue
(original residue number in PDB)		I16 K41 H57 E96 S97A L97B A98 Y99 Y151 D189 S190 K192 W215 G216 R217 G218
Binding residue
(residue number reindexed from 1)		I1 K29 H45 E88 S90 L91 A92 Y93 Y149 D191 S192 K194 W217 G218 R219 G220
Enzymatic activity
Catalytic site (original residue number in PDB) H57 D102 K192 G193 D194 S195 G196
Catalytic site (residue number reindexed from 1) H45 D96 K194 G195 D196 S197 G198
Enzyme Commision number 3.4.21.73: u-plasminogen activator.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:6a8g, PDBe:6a8g, PDBj:6a8g
PDBsum6a8g
PubMed30707839
UniProtP06869|UROK_MOUSE Urokinase-type plasminogen activator (Gene Name=Plau)

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