Structure of PDB 6a5r Chain A Binding Site BS01

Receptor Information
>6a5r Chain A (length=1408) Species: 644223 (Komagataella phaffii GS115) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SQFPYSSAPLRSVKEVQFGLLSPEEIRAISVVKIEYPEIMDESRQRPREG
GLNDPKLGSIDRNFKCQTCGEGMAECPGHFGHMELAKPVFHIGFIPKIKK
VCECICMNCGKLLLDETNPTMAQAIRIRDPKKRFNAVWQLCKTKMVCEAD
APKVVSRGGCGNTQPVVRKDGMKLWGTWKKSRDAQPERKLLTPGEILNVF
KHISPEDCFRLGFNEDYARPEWMIITVLPVPPPQVRPSIAMDETTQGQDD
LTHKLSDILKANINVQKLEMDGSPQHIINEVEQLLQFHVATYMDNDIAGQ
PQALQKSGRPVKAIRARLKGKEGRLRGNLMGKRVDFSARTVISGDPNLEL
DQVGVPISIAKTLSYPETVTQYNIHRLTEYVRNGPNEHPGAKYVIRDNGD
RIDLRYHKRAGDIVLQYGWKVERHLMDDDPVLFNRQPSLHKMSMMAHRVK
VMPYSTFRLNLSVTSPYNADFDGDEMNLHVPQSEETRAELSQLCAVPLQI
VSPQSNKPVMGIVQDTLCGVRKMTLRDTFIEYEQVMNMLFWVPSWDGVVP
QPAILKPKPLWTGKQLLSIAIPSGIHLQRTDGGNSLLSPKDNGMLIVDGK
VMFGVVDKKTVGSGGGGLIHTVMREKGPKICAELFGNIQKVVNYWLLHNG
FSIGIGDAIADASTMKEITHAISSAKEQVQEIIYKAQHNELELKPGMTLR
ESFEGEVSRTLNDARDSAGRSAEMNLKDLNNVKQMVSAGSKGSFINIAQM
SACVGQQMVEGKRIAFGFADRSLPHFTKDDFSPESKGFVENSYLRGLTPQ
EFFFHAMAGREGLIDTAVKTAETGYIQRRLVKALEDIMVHYDGTTRNSLG
DIIQFLYGEDGLDGTQVERQTIDTIPGSDKAFHKRYYVDLMDEKNSIKPD
VIEYAADILGDVELQKELNSEYEQLVSDRKFLREIVFVNGDHNWPLPVNL
RRIIQNAQQIFHLDRAKASDLTIPEIIHGVRDLCKKLFVLRGENELIKEA
QQNATSLFQCLVRARLATRRILEEFRLNRDAFEWVLGTIEAQFQRSLVHP
GEMVGVIAAQSIGEPATQMNVTLGVPRLKEILNVAKNIKTPALTVYLDRE
IALDIEKAKVIQSSIEYTTLKNVTSATEIYYDPDPTSTVIEEDFDTVEAY
FSQSPWLLRLELDRARMLDKQLTMNQVADKISEVFSDDLFVMWSEDNADK
LIIRCRVIEEDQMLKRIEAHMLDLIALRGIPGISKVYMVKHKVSVPDESG
EYKNEELWALETDGINLAEVMAVPGVDSSRTYSNSFVEILSVLGIEATRS
SLYKEILNVIAFDGSYVNYRHMALLVDVMTSRGYLMAITRHGINRADTGA
LMRCSFEETVEILFEAGAAAELDDCRGVSENVMLGQLAPMGTGAFDVMID
EKLLTSLP
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6a5r Structural basis of the nucleosome transition during RNA polymerase II passage.
Resolution8.7 Å
Binding residue
(original residue number in PDB)		A252 R447 D484 D486
Binding residue
(residue number reindexed from 1)		A240 R435 D472 D474
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0001055 RNA polymerase II activity
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0006366 transcription by RNA polymerase II
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005634 nucleus
GO:0005665 RNA polymerase II, core complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6a5r, PDBe:6a5r, PDBj:6a5r
PDBsum6a5r
PubMed30287617
UniProtC4R4Y0

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