Structure of PDB 6a0h Chain A Binding Site BS01

Receptor Information

>6a0h Chain A (length=302) Species: 9606 (Homo sapiens)

PLLVEGRRVRLPQSAGDLVRAHPPLEERARLLRGQSVQQVGPQGLLYVQQ
RELAVTSPKDGSISILGSDDATTSHIVVLRHTGNGATCLTHCDGTDTKAE
VPLIMNSIKSFSDQCGRLEVHLVGGFSDDRQLSQKLTHQLLSEFDRQEDD
IHLVTLCVTELNDREENENHFPVIYGIAVNIKTAEIYRASFQDRGPEEQL
RAARTLAGGPMISIYDAETEQLRIGPYSWTPFPHVDFWLHQDDKQILENL
STSPLAEPPHFVEHIRSTLMFLKKHPSPAHTLFSGNKALLYKKNEDGLWE
KI

Ligand information

>6a0h Chain C (length=4) Species: 32630 (synthetic construct)

NLAA

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6a0h Structural Analyses on the Deamidation of N-Terminal Asn in the Human N-Degron Pathway.
• Resolution: 3.185 Å
• Binding residue (original residue number in PDB): Q51 R52 T73 S75 S254 T255 E260 F264
• Binding residue (residue number reindexed from 1): Q50 R51 T72 S74 S251 T252 E257 F261

Enzymatic activity

• Enzyme Commision number: 3.5.1.121: protein N-terminal asparagine amidohydrolase.

Gene Ontology

Molecular Function

• GO:0005515 protein binding
• GO:0008418 protein-N-terminal asparagine amidohydrolase activity
• GO:0016787 hydrolase activity

Biological Process

• GO:0006511 ubiquitin-dependent protein catabolic process
• GO:0007613 memory
• GO:0008344 adult locomotory behavior

Cellular Component

• GO:0005634 nucleus
• GO:0005737 cytoplasm

External links

• PDB: RCSB:6a0h, PDBe:6a0h, PDBj:6a0h
• PDBsum: 6a0h
• PubMed: 31968674
• UniProt: Q96AB6|NTAN1_HUMAN Protein N-terminal asparagine amidohydrolase (Gene Name=NTAN1)