Structure of PDB 5zvu Chain A Binding Site BS01

Receptor Information

>5zvu Chain A (length=381) Species: 99287 (Salmonella enterica subsp. enterica serovar Typhimurium str. LT2)

SMQKLINSVQNYAWGSKTALTELYGIANPQQQPMAELWMGAHPKSSSRIT
TVSLRDAIEKNKTAMLGEAVANRFGELPFLFKVLCAAQPLSIQVHPNKRN
SEIGFAKENAPMDRNYKDPNHAPELVFALTPFLAMNAFREFSDIVSLLQP
VAGAHSAIAHFLQVPNAERLSQLFASLLNMQGEEKSRALAVLKAALNSQQ
GEPWQTIRVISEYYPDDSGLFSPLLLNVVKLNPGEAMFLFAETPHAYLQG
VALEVMANSDNVLRAGLTPKYIDIPELVANVKFEPKPAGELLTAPVKSGA
ELDFPIPVDDFAFSLHDLALQETSIGQHSAAILFCVEGEAVLRKDEQRLV
LKPGESAFIGADESPVNASGTGRLARVYNKL

Ligand information

• Ligand ID: ZN
• InChI: InChI=1S/Zn/q+2
• InChIKey: PTFCDOFLOPIGGS-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Zn++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Zn+2]
• Formula: Zn
• Name: ZINC ION
• ChEMBL: CHEMBL1236970
• DrugBank: DB14532
• PDB chain: 5zvu Chain A Residue 401

Receptor-Ligand Complex Structure

Structure summary

• PDB: 5zvu Structural and functional insights into phosphomannose isomerase: the role of zinc and catalytic residues.
• Resolution: 2.2 Å
• Binding residue (original residue number in PDB): H99 E134 H255
• Binding residue (residue number reindexed from 1): H95 E124 H245
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 5.3.1.8: mannose-6-phosphate isomerase.

Gene Ontology

Molecular Function

• GO:0004476 mannose-6-phosphate isomerase activity
• GO:0008270 zinc ion binding
• GO:0016853 isomerase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0005975 carbohydrate metabolic process
• GO:0009298 GDP-mannose biosynthetic process

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol

External links

• PDB: RCSB:5zvu, PDBe:5zvu, PDBj:5zvu
• PDBsum: 5zvu
• PubMed: 31063150
• UniProt: P25081|MANA_SALTY Mannose-6-phosphate isomerase (Gene Name=manA)