Structure of PDB 5zvm Chain A Binding Site BS01

Receptor Information
>5zvm Chain A (length=69) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TQNVLYENQKQIANQFNKAISQIQESLTTTSTALGKLQDVVNQNAQALNT
LVKQLSSNFGAISSVLNDI
Ligand information
>5zvm Chain a (length=29) Species: 32630 (synthetic construct) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
INVTFLDLEYEMKKLEEAIKKLEESYIDL
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB5zvm A pan-coronavirus fusion inhibitor targeting the HR1 domain of human coronavirus spike.
Resolution3.3 Å
Binding residue
(original residue number in PDB)		Q902 F909 N910 I913 S914 Q917 L920 T921 S924 L927 G928 Q931 N935 A938 Q939
Binding residue
(residue number reindexed from 1)		Q9 F16 N17 I20 S21 Q24 L27 T28 S31 L34 G35 Q38 N42 A45 Q46
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Biological Process
GO:0019064 fusion of virus membrane with host plasma membrane
GO:0039654 fusion of virus membrane with host endosome membrane
GO:0046813 receptor-mediated virion attachment to host cell
GO:0075509 endocytosis involved in viral entry into host cell
Cellular Component
GO:0016020 membrane
GO:0019031 viral envelope
GO:0055036 virion membrane

View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:5zvm, PDBe:5zvm, PDBj:5zvm
PDBsum5zvm
PubMed30989115
UniProtP59594|SPIKE_SARS Spike glycoprotein (Gene Name=S)

[Back to BioLiP]