Structure of PDB 5zt7 Chain A Binding Site BS01

Receptor Information

>5zt7 Chain A (length=254) Species: 224308 (Bacillus subtilis subsp. subtilis str. 168)

KQAILYVGHGSRVKKAQQEAAAFLEGCKAHISVPVQEISFLELQEPTIET
GFEACVKQGATHIAVVPLLLLTAAHAKHDIPEEIVRVASRYPSVRISYGK
PIGIDEEVVKAVYHRMKDIGVPYENARVVLIGRGSSDPDVKRDVTGIANL
LQEMVPVKEVIPCFLTACGPNYKEVFSELEKDDGITTFIVPYLLFTGMLM
NEIEREVQKLKAHNPNVYLSSYIGFHPHVKNAFLNRVRETAANSEGQFDF
DGGS

Ligand information

• Ligand ID: CO
• InChI: InChI=1S/Co/q+2
• InChIKey: XLJKHNWPARRRJB-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Co+2]
  CACTVS 3.341: [Co++]
• Formula: Co
• Name: COBALT (II) ION
• DrugBank: DB14205
• PDB chain: 5zt7 Chain A Residue 301

Receptor-Ligand Complex Structure

Structure summary

• PDB: 5zt7 Structure of sirohydrochlorin ferrochelatase SirB: the last of the structures of the class II chelatase family.
• Resolution: 2.94 Å
• Binding residue (original residue number in PDB): H31 K231
• Binding residue (residue number reindexed from 1): H30 K230
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 4.99.1.4: sirohydrochlorin ferrochelatase.

Gene Ontology

Molecular Function

• GO:0016829 lyase activity
• GO:0046872 metal ion binding
• GO:0051266 sirohydrochlorin ferrochelatase activity

Biological Process

• GO:0006779 porphyrin-containing compound biosynthetic process
• GO:0019354 siroheme biosynthetic process

External links

• PDB: RCSB:5zt7, PDBe:5zt7, PDBj:5zt7
• PDBsum: 5zt7
• PubMed: 30778451
• UniProt: O34632|SIRB_BACSU Sirohydrochlorin ferrochelatase (Gene Name=sirB)