Structure of PDB 5zsm Chain A Binding Site BS01

Receptor Information

>5zsm Chain A (length=774) Species: 9544 (Macaca mulatta)

ARWFPKTLPCDVTLDVSKNHVIVDCTDKHLTEIPGGIPTNTTNLTLTINH
IPDISPASFHRLVHLVEIDFRCNCVPIRLGSKSNMCPRRLQIKPRSFSGL
TYLKSLYLDGNQLLEIPQGLPPSLQLLSLEANNIFSIRKEQLTELANIEI
LYLGQNCYYRNPCYVSYSIEKDAFLNLTKLKVLSLKDNNVTTVPTVLPST
LTELYLYNNMIAEIQEDDFNNLNQLQILDLSGNCPRCYNAPFPCTPCKNN
SPLQIPVNAFDALTELKVLRLHSNSLQHVPPRWFKNINNLQELDLSQNFL
AKEIGDAKFLHFLPNLIQLDLSFNFELQVYRASMNLSQAFSSLKSLKILR
IRGYVFKELKSFQLSPLHNLQNLEVLDLGTNFIKIANLSMFKQFKRLKVI
DLSVNKISPQVLEQLYYFRYDKYARSCRSCYKYGQTLDLSKNSIFFIKSS
DFQHLSFLKCLNLSGNLISQTLNGSEFQPLAELRYLDFSNNRLDLLHSTA
FEELRKLEVLDISSNSHYFQSEGITHMLNFTKNLKVLQKLMMNDNDISSS
TSRTMESESLRTLEFRGNHLDVLWRDGDNRYLQLFKNLLKLEELDISKNS
LSFLPSGVFDGMPPNLKNLSLAKNGLKSFIWEKLRYLKNLETLDLSHNQL
TTVPERLSNCSRSLKNLILKNNQIRSLTKYFLQDAFQLRYLDLSSNKIQM
IQKTSFPENVLNNLKMLLLHHNRFLCTCDAVWFVWWVQHTEVTIPYLATD
VTCVGPGAHKGQSVISLDLYTCEL

Ligand information

>5zsm Chain D (length=5)

guccc

.....

Receptor-Ligand Complex Structure

Structure summary

• PDB: 5zsm To be published
• Resolution: 2.5 Å
• Binding residue (original residue number in PDB): H76 C98 L105 D135 E156 Q181 Y184 R186 R467 A472 R473 S474 C475
• Binding residue (residue number reindexed from 1): H50 C72 L79 D109 E130 Q155 Y158 R160 R419 A424 R425 S426 C427

Gene Ontology

Molecular Function

• GO:0004888 transmembrane signaling receptor activity

Biological Process

• GO:0002224 toll-like receptor signaling pathway
• GO:0006955 immune response

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:5zsm, PDBe:5zsm, PDBj:5zsm
• PDBsum: 5zsm
• PubMed: 30566863
• UniProt: B3Y653