Structure of PDB 5zsb Chain A Binding Site BS01

Receptor Information

>5zsb Chain A (length=773) Species: 9544 (Macaca mulatta)

ARWFPKTLPCDVTLDVSKNHVIVDCTDKHLTEIPGGIPTNTTNLTLTINH
IPDISPASFHRLVHLVEIDFRCNCVPIRLGSKSNMCPRRLQIKPRSFSGL
TYLKSLYLDGNQLLEIPQGLPPSLQLLSLEANNIFSIRKEQLTELANIEI
LYLGQNCYYRNPCYVSYSIEKDAFLNLTKLKVLSLKDNNVTTVPTVLPST
LTELYLYNNMIAEIQEDDFNNLNQLQILDLSGNCPRCYNAPFPCTPCKNN
SPLQIPVNAFDALTELKVLRLHSNSLQHVPPRWFKNINNLQELDLSQNFL
AKEIGDAKFLHFLPNLIQLDLSFNFELQVYRASMNLSQAFSSLKSLKILR
IRGYVFKELKSFQLSPLHNLQNLEVLDLGTNFIKIANLSMFKQFKRLKVI
DLSVNKISPVLEQLYYFRYDKYARSCRSCYKYGQTLDLSKNSIFFIKSSD
FQHLSFLKCLNLSGNLISQTLNGSEFQPLAELRYLDFSNNRLDLLHSTAF
EELRKLEVLDISSNSHYFQSEGITHMLNFTKNLKVLQKLMMNDNDISSST
SRTMESESLRTLEFRGNHLDVLWRDGDNRYLQLFKNLLKLEELDISKNSL
SFLPSGVFDGMPPNLKNLSLAKNGLKSFIWEKLRYLKNLETLDLSHNQLT
TVPERLSNCSRSLKNLILKNNQIRSLTKYFLQDAFQLRYLDLSSNKIQMI
QKTSFPENVLNNLKMLLLHHNRFLCTCDAVWFVWWVQHTEVTIPYLATDV
TCVGPGAHKGQSVISLDLYTCEL

Ligand information

>5zsb Chain C (length=5)

auuaa

.....

Receptor-Ligand Complex Structure

Structure summary

• PDB: 5zsb To be published
• Resolution: 2.7 Å
• Binding residue (original residue number in PDB): I74 H76 C98 L105 G106 S107 D135 E156 Q181 Y184 R186 R467 Y468 D469 A472 R473 S474 C475
• Binding residue (residue number reindexed from 1): I48 H50 C72 L79 G80 S81 D109 E130 Q155 Y158 R160 R418 Y419 D420 A423 R424 S425 C426

Gene Ontology

Molecular Function

• GO:0004888 transmembrane signaling receptor activity

Biological Process

• GO:0002224 toll-like receptor signaling pathway
• GO:0006955 immune response

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:5zsb, PDBe:5zsb, PDBj:5zsb
• PDBsum: 5zsb
• PubMed: 30566863
• UniProt: B3Y653