Structure of PDB 5zod Chain A Binding Site BS01

Receptor Information
>5zod Chain A (length=260) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GIQGLAKLIADVAPSAIRENDIKSYFGRKVAIDASMSHLMGMFYRTIRMM
ENGIKPVYVFDGKPPQNDECKHLLSLMGIPYLDAPSEAEASCAALVKAGK
VYAAATEDMDCLTFGSPVLMRHLTASEAKKLPIQEFHLSRILQELGLNQE
QFVDLCILLGSDYCESIRGIGPKRAVDLIQKHKSIEEIVRRLDPNKYPVP
ENWLHKEAHQLFLEPEVLDPESVELKWSEPNEEELIKFMCGEKQFSEERI
RSGVKRLSKS
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain5zod Chain A Residue 402 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5zod Structural basis of 5' flap recognition and protein-protein interactions of human flap endonuclease 1.
Resolution1.9 Å
Binding residue
(original residue number in PDB)		E160 D179 D181 D233
Binding residue
(residue number reindexed from 1)		E89 D108 D110 D162
Annotation score4
Enzymatic activity
Enzyme Commision number 3.1.-.-
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003824 catalytic activity
GO:0004518 nuclease activity
GO:0016788 hydrolase activity, acting on ester bonds

View graph for
Molecular Function
External links
PDB RCSB:5zod, PDBe:5zod, PDBj:5zod
PDBsum5zod
PubMed30295841
UniProtP39748|FEN1_HUMAN Flap endonuclease 1 (Gene Name=FEN1)

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