Structure of PDB 5zhx Chain A Binding Site BS01

Receptor Information
>5zhx Chain A (length=469) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DAGLISPLVQLLNSKDQEVLLQTGRALGNICYDSHSLQAQLINMGVIPTL
VKLLGIHCQNAALTEMCLVAFGNLAELESSKEQFASTNIAEELVKLFKKQ
IEHDKREMIFEVLAPLAENDAIKLQLVEAGLVECLLEIVQQKVDSDKEDD
ITELKTGSDLMVLLLLGDESMQKLFEGGKGSVFQRVLSWIPSNNHQLQLA
GALAIANFARNDANCIHMVDNGIVEKLMDLLDRHVEDGNVTVQHAALSAL
RNLAIPVINKAKMLSAGVTEAVLKFLKSEMPPVQFKLLGTLRMLIDAQAE
AAEQLGKNVKLVERLVEWCEAKDHAGVMGESNRLLSALIRHSKSKDVIKT
IVQSGGIKHLVTMATSEHVIMQNEALVALALIAALELGTAEKDLESAKLV
QILHRLLADERSAPEIKYNSMVLICALMGSECLHKEVQDLAFLDVVSKLR
SHENKSVAQQASLTEQRLT
Ligand information
Ligand IDFAR
InChIInChI=1S/C15H26/c1-6-14(4)10-8-12-15(5)11-7-9-13(2)3/h6,9,12H,7-8,10-11H2,1-5H3/b14-6+,15-12+
InChIKeyJXBSHSBNOVLGHF-BUJBXKITSA-N
SMILES
SoftwareSMILES
CACTVS 3.341
OpenEye OEToolkits 1.5.0		CC=C(C)CCC=C(C)CCC=C(C)C
OpenEye OEToolkits 1.5.0C\C=C(/C)\CC\C=C(/C)\CCC=C(C)C
CACTVS 3.341C\C=C(C)\CC\C=C(C)\CCC=C(C)C
ACDLabs 10.04C(=C/C)(\CC/C=C(/CC/C=C(\C)C)C)C
FormulaC15 H26
NameFARNESYL
ChEMBL
DrugBank
ZINC
PDB chain5zhx Chain e Residue 201 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB5zhx GEF mechanism revealed by the structure of SmgGDS-558 and farnesylated RhoA complex and its implication for a chaperone mechanism.
Resolution3.5 Å
Binding residue
(original residue number in PDB)		Q124 L136 M152
Binding residue
(residue number reindexed from 1)		Q38 L50 M66
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005085 guanyl-nucleotide exchange factor activity
Biological Process
GO:0043547 positive regulation of GTPase activity

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:5zhx, PDBe:5zhx, PDBj:5zhx
PDBsum5zhx
PubMed30190425
UniProtP52306|GDS1_HUMAN Rap1 GTPase-GDP dissociation stimulator 1 (Gene Name=RAP1GDS1)

[Back to BioLiP]