Structure of PDB 5ze3 Chain A Binding Site BS01

Receptor Information

>5ze3 Chain A (length=441) Species: 9606 (Homo sapiens)

EQPLVRLRGGAYIGEGRVEVLKNGEWGTVCDDKWDLVSASVVCRELGFGS
AKEAVTGSRLGQGIGPIHLNEIQCTGNEKSIIDCKFNAESQGCNHEEDAG
VRCNTPAMGLQKKLRLNGGRNPYEGRVEVLVERQGSLVWGMVCGQNWGIV
EAMVVCRQLGLGFASNAFQETWYWHGDVNSNKVVMSGVKCSGTELSLAHC
RHDGEDVACPQGGVQYGAGVACSETAPDLVLNAEMVQQTTYLEDRPMFLL
QCAMEENCLSASAAQTDPTTGYRRLLRFSSQIHNNGQSDFRPKNGRHAWI
WHDCHRHYHSMEVFTHYDLLNLNGTKVAEGHKASFCLEDTECEGDIQKNY
ECANFGDQGITMGCWDMYRHDIDCQWVDITDVPPGDYLFQVVINPNFEVA
ESDYSNNIMKCRSRYDGHRIWMYNCHIGGSFSEETEKKFEH

Ligand information

• Ligand ID: CA
• InChI: InChI=1S/Ca/q+2
• InChIKey: BHPQYMZQTOCNFJ-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Ca++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Ca+2]
• Formula: Ca
• Name: CALCIUM ION
• DrugBank: DB14577
• PDB chain: 5ze3 Chain A Residue 801

Receptor-Ligand Complex Structure

Structure summary

• PDB: 5ze3 Crystal structure of human lysyl oxidase-like 2 (hLOXL2) in a precursor state.
• Resolution: 2.4 Å
• Binding residue (original residue number in PDB): D549 L550 E722 D724 N727 N728
• Binding residue (residue number reindexed from 1): D228 L229 E401 D403 N406 N407
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 1.4.3.13: protein-lysine 6-oxidase.

Gene Ontology

Molecular Function

• GO:0005507 copper ion binding
• GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:5ze3, PDBe:5ze3, PDBj:5ze3
• PDBsum: 5ze3
• PubMed: 29581294
• UniProt: Q9Y4K0|LOXL2_HUMAN Lysyl oxidase homolog 2 (Gene Name=LOXL2)