Structure of PDB 5z8h Chain A Binding Site BS01

Receptor Information
>5z8h Chain A (length=333) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HHHMLHLLEQIRAYCETCWEWQEAHEPNPMPAPVEHQICPAVCVLMKLSF
DEEHRHAMNELGGLQAIAELLQVDCEMYGLTNDHYSITLRRYAGMALTNL
TFGDVANKATLCSMKGCMRALVAQLKSESEDLQQVIASVLRNLSWRADVN
SKKTLREVGSVKALMECALEVKKESTLKSVLSALWNLSAHCTENKADICA
VDGALAFLVGTLTYRSQTNTLAIIESGGGILRNVSSLIATNEDHRQILRE
NNCLQTLLQHLKSHSLTIVSNACGTLWNLSARNPKDQEALWDMGAVSMLK
NLIHSKHKMIAMGSAAALRNLMANRPAKYKDAN
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5z8h APC with an inhibitor
Resolution1.79 Å
Binding residue
(original residue number in PDB)		R463 M503 T506 N507 F510 G511 K516 Q542 V543 R549 N550 W553 S590 W593 N594 N641
Binding residue
(residue number reindexed from 1)		R55 M95 T98 N99 F102 G103 K108 Q134 V135 R141 N142 W145 S182 W185 N186 N233
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0008013 beta-catenin binding
Biological Process
GO:0030178 negative regulation of Wnt signaling pathway

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Molecular Function
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Biological Process
External links
PDB RCSB:5z8h, PDBe:5z8h, PDBj:5z8h
PDBsum5z8h
PubMed
UniProtP25054|APC_HUMAN Adenomatous polyposis coli protein (Gene Name=APC)

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