Structure of PDB 5z62 Chain A Binding Site BS01

Receptor Information
>5z62 Chain A (length=513) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MFADRWLFSTNHKDIGTLYLLFGAWAGVLGTALSLLIRAELGQPGNLLGN
DHIYNVIVTAHAFVMIFFMVMPIMIGGFGNWLVPLMIGAPDMAFPRMNNM
SFWLLPPSLLLLLASAMVEAGAGTGWTVYPPLAGNYSHPGASVDLTIFSL
HLAGVSSILGAINFITTIINMKPPAMTQYQTPLFVWSVLITAVLLLLSLP
VLAAGITMLLTDRNLNTTFFDPAGGGDPILYQHLFWFFGHPEVYILILPG
FGMISHIVTYYSGKKEPFGYMGMVWAMMSIGFLGFIVWAHHMFTVGMDVD
TRAYFTSATMIIAIPTGVKVFSWLATLHGSNMKWSAAVLWALGFIFLFTV
GGLTGIVLANSSLDIVLHDTYYVVAHFHYVLSMGAVFAIMGGFIHWFPLF
SGYTLDQTYAKIHFTIMFIGVNLTFFPQHFLGLSGMPRRYSDYPDAYTTW
NILSSVGSFISLTAVMLMIFMIWEAFASKRKVLMVEEPSMNLEWLYGCPP
PYHTFEEPVYMKS
Ligand information
Ligand IDCU
InChIInChI=1S/Cu/q+2
InChIKeyJPVYNHNXODAKFH-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Cu+2]
CACTVS 3.341[Cu++]
FormulaCu
NameCOPPER (II) ION
ChEMBL
DrugBankDB14552
ZINC
PDB chain5z62 Chain A Residue 601 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5z62 Structure of the intact 14-subunit human cytochrome c oxidase.
Resolution3.6 Å
Binding residue
(original residue number in PDB)		H240 H290 H291
Binding residue
(residue number reindexed from 1)		H240 H290 H291
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) H61 D91 W126 S156 S157 H240 E242 Y244 S255 H290 H291 T316 K319 R438
Catalytic site (residue number reindexed from 1) H61 D91 W126 S156 S157 H240 E242 Y244 S255 H290 H291 T316 K319 R438
Enzyme Commision number 7.1.1.9: cytochrome-c oxidase.
Gene Ontology
Molecular Function
GO:0004129 cytochrome-c oxidase activity
GO:0005515 protein binding
GO:0020037 heme binding
GO:0046872 metal ion binding
Biological Process
GO:0001666 response to hypoxia
GO:0006119 oxidative phosphorylation
GO:0006123 mitochondrial electron transport, cytochrome c to oxygen
GO:0006979 response to oxidative stress
GO:0009060 aerobic respiration
GO:0015990 electron transport coupled proton transport
GO:0021549 cerebellum development
GO:0045333 cellular respiration
GO:0046688 response to copper ion
GO:0051602 response to electrical stimulus
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0016020 membrane
GO:0031966 mitochondrial membrane
GO:0045277 respiratory chain complex IV

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:5z62, PDBe:5z62, PDBj:5z62
PDBsum5z62
PubMed30030519
UniProtP00395|COX1_HUMAN Cytochrome c oxidase subunit 1 (Gene Name=MT-CO1)

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