Structure of PDB 5z2m Chain A Binding Site BS01

Receptor Information
>5z2m Chain A (length=172) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KKVLLKVIILGDSGVGKTSLMNQYVNKKFSNQYKATIGADFLTKEVMVDD
RLVTMQIWDTAGLERFQSLGVAFYRGADCCVLVFDVTAPNTFKTLDSWRD
EFLIQASPRDPENFPFVVLGNKIDLENRQVATKRAQAWCYSKNNIPYFET
SAKEAINVEQAFQTIARNALKQ
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain5z2m Chain A Residue 201 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5z2m A non-canonical GTPase interaction enables ORP1L-Rab7-RILP complex formation and late endosome positioning.
Resolution2.142 Å
Binding residue
(original residue number in PDB)		T22 T40
Binding residue
(residue number reindexed from 1)		T18 T36
Annotation score1
Enzymatic activity
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding

View graph for
Molecular Function
External links
PDB RCSB:5z2m, PDBe:5z2m, PDBj:5z2m
PDBsum5z2m
PubMed30012887
UniProtP51150|RAB7A_MOUSE Ras-related protein Rab-7a (Gene Name=Rab7a)

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