Structure of PDB 5yxl Chain A Binding Site BS01

Receptor Information
>5yxl Chain A (length=220) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TPDQQTLLHFIMDSYNKQRMPQEITNKILKEEFSAEENFLILTEMATNHV
QVLVEFTKKLPGFQTLDHEDQIALLKGSAVEAMFLRSAEIFNKSDLLEER
IRNSGISDEYITPMFSFYKSIGELKMTQEEYALLTAIVILSPDRQYIKDR
EAVEKLQEPLLDVLQKLCKIHQPENPQHFACLLGRLTELRTFNHHHAEML
MSWRVNDHKFTPLLCEIWDV
Ligand information
Receptor-Ligand Complex Structure
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PDB5yxl A ligand M binding to FXR
Resolution2.24 Å
Binding residue
(original residue number in PDB)		H70 Q73 L221
Binding residue
(residue number reindexed from 1)		H68 Q71 L213
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
GO:0032052 bile acid binding
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0038183 bile acid signaling pathway

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Molecular Function
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Biological Process
External links
PDB RCSB:5yxl, PDBe:5yxl, PDBj:5yxl
PDBsum5yxl
PubMed
UniProtQ96RI1|NR1H4_HUMAN Bile acid receptor (Gene Name=NR1H4)

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