Structure of PDB 5ywt Chain A Binding Site BS01

Receptor Information
>5ywt Chain A (length=222) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TLPHGHMQTLIFLDLEATGLPSSRPEVTELCLLAVHRRALENTSISQGHP
PPVPRPPRVVDKLSLCIAPGKACSPGASEITGLSKAELEVQGRQRFDDNL
AILLRAFLQRQPQPCCLVAHNGDRYDFPLLQTELARLSTPSPLDGTFCVD
SIAALKALEQKSYSLGSIYTRLYWQAPTDSHTAEGDVLTLLSICQWKPQA
LLQWVDEHARPFSTVKPMYGTP
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5ywt Structural basis for overhang excision and terminal unwinding of DNA duplexes by TREX1
Resolution1.7 Å
Binding residue
(original residue number in PDB)		E20 A21 G23 L24 I84 H124 N125 R128 Y129 A157 K160 S176 Y177 S178 L179 H195
Binding residue
(residue number reindexed from 1)		E16 A17 G19 L20 I80 H120 N121 R124 Y125 A153 K156 S162 Y163 S164 L165 H181
Enzymatic activity
Enzyme Commision number 3.1.11.2: exodeoxyribonuclease III.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0008408 3'-5' exonuclease activity

View graph for
Molecular Function
External links
PDB RCSB:5ywt, PDBe:5ywt, PDBj:5ywt
PDBsum5ywt
PubMed29734329
UniProtQ91XB0|TREX1_MOUSE Three-prime repair exonuclease 1 (Gene Name=Trex1)

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