Structure of PDB 5yws Chain A Binding Site BS01

Receptor Information
>5yws Chain A (length=231) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TLPHGHMQTLIFLDLEATGLPSSRPEVTELCLLAVHRRALENTSISQGHP
PPVPRPPRVVDKLSLCIAPGKACSPGASEITGLSKAELEVQGRQRFDDNL
AILLRAFLQRQPQPCCLVAHNGDRYDFPLLQTELARLSTPSPLDGTFCVD
SIAALKALEQASSPSGNGSRKSYSLGSIYTRLYWQAPTDSHTAEGDVLTL
LSICQWKPQALLQWVDEHARPFSTVKPMYGT
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5yws Structural basis for overhang excision and terminal unwinding of DNA duplexes by TREX1
Resolution2.0 Å
Binding residue
(original residue number in PDB)		E20 A21 L24 S26 I84 H124 N125 R128 Y129 R174 S176 Y177 S178 L179 H195
Binding residue
(residue number reindexed from 1)		E16 A17 L20 S22 I80 H120 N121 R124 Y125 R170 S172 Y173 S174 L175 H191
Enzymatic activity
Enzyme Commision number 3.1.11.2: exodeoxyribonuclease III.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0008408 3'-5' exonuclease activity

View graph for
Molecular Function
External links
PDB RCSB:5yws, PDBe:5yws, PDBj:5yws
PDBsum5yws
PubMed29734329
UniProtQ91XB0|TREX1_MOUSE Three-prime repair exonuclease 1 (Gene Name=Trex1)

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