Structure of PDB 5yvi Chain A Binding Site BS01

Receptor Information
>5yvi Chain A (length=828) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EWKPDEQGLQQILQLLKESQSPDTTIQRTVQQKLEQLNQYPDFNNYLIFV
LTKLKSEDEPTRSLSGLILKNNVKAHFQNFPNGVTDFIKSECLNNIGDSS
PLIRATVGILITTIASKGELQNWPDLLPKLCSLLDSEDYNTCEGAFGALQ
KICEDSAEILDSLDRPLNIMIPKFLQFFKHSSPKIRSHAVACVNQFIISR
TQALMLHIDSFIENLFALAGDEEPEVRKNVCRALVMLLEVRMDRLLPHMH
NIVEYMLQRTQDQDENVALEACEFWLTLAEQPICKDVLVRHLPKLIPVLV
NGMKYSDIDIILLDWNLRKCSAAALDVLANVYRDELLPHILPLLKELLFH
HEWVVKESGILVLGAIAEGCMQGMIPYLPELIPHLIQCLSDKKALVRSIT
CWTLSRYAHWVVSQPPDTYLKPLMTELLKRILDSNKRVQEAACSAFATLE
EEACTELVPYLAYILDTLVFAFSKYQHKNLLILYDAIGTLADSVGHHLNK
PEYIQMLMPPLIQKWNMLKDEDKDLFPLLECLSSVATALQSGFLPYCEPV
YQRCVNLVQKTLAQAMLNNAQPDQYEAPDKDFMIVALDLLSGLAEGLGGN
IEQLVARSNILTLMYQCMQDKMPEVRQSSFALLGDLTKACFQHVKPCIAD
FMPILGTNLNPEFISVCNNATWAIGEISIQMGIEMQPYIPMVLHQLVEII
NRPNTPKTLLENTAITIGRLGYVCPQEVAPMLQQFIRPWCTSLRNIRDNE
EKDSAFRGICTMSVNPSGVIQDFIFFCDAVASWINPKDDLRDMFCKILHG
FKNQENWRRFSDQFPLPLKERLAAFYGV
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5yvi Nuclear Import Receptor Inhibits Phase Separation of FUS through Binding to Multiple Sites.
Resolution2.9 Å
Binding residue
(original residue number in PDB)		K377 A380 A381 D384 L419 A423 W460 E498 A499 S502 A505 E509 D543 G546 P585 E588 S591 S592 D646 D693 N726 N727 W730 E769 N770
Binding residue
(residue number reindexed from 1)		K319 A322 A323 D326 L361 A365 W402 E440 A441 S444 A447 E451 D485 G488 P527 E530 S533 S534 D588 D635 N668 N669 W672 E711 N712
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0031267 small GTPase binding
Biological Process
GO:0006606 protein import into nucleus
GO:0006886 intracellular protein transport

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Molecular Function
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Biological Process
External links
PDB RCSB:5yvi, PDBe:5yvi, PDBj:5yvi
PDBsum5yvi
PubMed29677513
UniProtQ92973|TNPO1_HUMAN Transportin-1 (Gene Name=TNPO1)

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