Structure of PDB 5yvh Chain A Binding Site BS01

Receptor Information

>5yvh Chain A (length=809) Species: 9606 (Homo sapiens)

WKPDEQGLQQILQLLKESQSPDTTIQRTVQQKLEQLNQYPDFNNYLIFVL
TKLKSEDEPTRSLSGLILKNNVKAHFQNFPNGVTDFIKSECLNNIGDSSP
LIRATVGILITTIASKGELQNWPDLLPKLCSLLDSEDYNTCEGAFGALQK
ICEDSAEILDSDVLDRPLNIMIPKFLQFFKHSSPKIRSHAVACVNQFIIS
RTQALMLHIDSFIENLFALAGDEEPEVRKNVCRALVMLLEVRMDRLLPHM
HNIVEYMLQRTQDQDENVALEACEFWLTLAEQPICKDVLVRHLPKLIPVL
VNGMKYSDIDIIDWNLRKCSAAALDVLANVYRDELLPHILPLLKELLFHH
EWVVKESGILVLGAIAEGCMQGMIPYLPELIPHLIQCLSDKKALVRSITC
WTLSRYAHWVVSQPPDTYLKPLMTELLKRILDSNKRVQEAACSAFATLEE
EACTELVPYLAYILDTLVFAFSKYQHKNLLILYDAIGTLADSVGHHLNKP
EYIQMLMPPLIQKWNMLKDEDKDLFPLLECLSSVATALQSGFLPYCEPVY
QRCVNLVQKTLAQAMLNNAQPDQYEAPDKDFMIVALDLLSGLAEGLGGNI
EQLVARSNILTLMYQCMQDKMPEVRQSSFALLGDLTKACFQHVKPCIADF
MPILGTNLNPEFISVCNNATWAIGEISIQMMQPYIPMVLHQLVEIINRPN
TPKTLLENTAITIGRLGYVCPQQFIRPWCTSLRNIRDNEEKDSAFRGICT
MISVNPDFIFFCDAVASWINPKDDLRDMFCKILHGFKNQRRFSDQFPLPL
KERLAAFYG

Ligand information

>5yvh Chain B (length=19) Species: 9606 (Homo sapiens)

PGKMDSRGEHRQDRRERPY

Receptor-Ligand Complex Structure

Structure summary

• PDB: 5yvh Nuclear Import Receptor Inhibits Phase Separation of FUS through Binding to Multiple Sites.
• Resolution: 3.15 Å
• Binding residue (original residue number in PDB): A381 D384 W460 R495 S502 T506 E509 D543 G546 D550 E588 S591 D646 E653 D693 N726 N727 W730 N770
• Binding residue (residue number reindexed from 1): A322 D325 W401 R436 S443 T447 E450 D484 G487 D491 E529 S532 D587 E594 D634 N667 N668 W671 N708

Gene Ontology

Molecular Function

• GO:0031267 small GTPase binding

Biological Process

• GO:0006606 protein import into nucleus
• GO:0006886 intracellular protein transport

External links

• PDB: RCSB:5yvh, PDBe:5yvh, PDBj:5yvh
• PDBsum: 5yvh
• PubMed: 29677513
• UniProt: Q92973|TNPO1_HUMAN Transportin-1 (Gene Name=TNPO1)