Structure of PDB 5yki Chain A Binding Site BS01

Receptor Information
>5yki Chain A (length=383) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GRSRLLEDFRNNRYPNLQLREIAGHIMEFSQDQHGSRFIQLKLERATPAE
RQLVFNEILQAAYQLMVDVFGNYVIQKFFEFGSLEQKLALAERIRGHVLS
LALQMYGCRVIQKALEFIPSDQQNEMVRELHQHTEQLVQDQYGNYVIQHV
LEHGRPEDKSKIVAEIRGNVLVLSQHKFASNVVEKCVTHASRTERAVLID
EVCTMNDGPHSALYTMMKDQYANYVVQKMIDVAEPGQRKIVMHELHQHTE
QLVQDQYGNYVIQHVLEHGRPEDKSKIVAEIRGNVLVLSQHKFASNVVEK
CVTHASRTERAVLIDEVCTMNDGPHSALYTMMKDQYANYVVQKMIDVAEP
GQRKIVMHKIRPHIATLRKYTYGKHILAKLEKY
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5yki Expanding RNA binding specificity and affinity of engineered PUF domains.
Resolution2.25 Å
Binding residue
(original residue number in PDB)		R37 Q40 N72 Y73 R109 Q112 N144 Y145 K177 N181 E184 Y221 N223 Y224 N259 Y260 Q263 K292 N296 E299 Y336 N338 Y339 H375
Binding residue
(residue number reindexed from 1)		R37 Q40 N72 Y73 R109 Q112 N144 Y145 K177 N181 E184 Y221 N223 Y224 N259 Y260 Q263 K292 N296 E299 Y336 N338 Y339 H375
Binding affinityPDBbind-CN: Kd=1.5nM
Enzymatic activity
Enzyme Commision number ?
Gene Ontology

View graph for
Molecular Function
External links
PDB RCSB:5yki, PDBe:5yki, PDBj:5yki
PDBsum5yki
PubMed29490074
UniProtQ14671|PUM1_HUMAN Pumilio homolog 1 (Gene Name=PUM1)

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