Structure of PDB 5yis Chain A Binding Site BS01

Receptor Information
>5yis Chain A (length=113) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KTFKQRRSFEQRVEDVRLIREQHPTKIPVIIERYKGEKQLPVLDKTKFLV
PDHVNMSELIKIIRRRLQLNANQAFFLLVNGHSMVSVSTPISEVYESERD
EDGFLYMVYASQE
Ligand information
>5yis Chain C (length=26) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
VEEEWVIVSDEEIEEARQKAPLEITE
Receptor-Ligand Complex Structure
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PDB5yis Potent and specific Atg8-targeting autophagy inhibitory peptides from giant ankyrins.
Resolution2.201 Å
Binding residue
(original residue number in PDB)		I23 K51 F52 L53 H57 S61 E62 K65 I66 R70 V91 S92 F108
Binding residue
(residue number reindexed from 1)		I19 K47 F48 L49 H53 S57 E58 K61 I62 R66 V87 S88 F104
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005515 protein binding
Biological Process
GO:0000423 mitophagy
GO:0006914 autophagy
GO:0009267 cellular response to starvation
GO:0051649 establishment of localization in cell
GO:0070254 mucus secretion
GO:0070257 positive regulation of mucus secretion
Cellular Component
GO:0000421 autophagosome membrane
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005776 autophagosome
GO:0005856 cytoskeleton
GO:0005874 microtubule
GO:0005930 axoneme
GO:0012505 endomembrane system
GO:0016020 membrane
GO:0031410 cytoplasmic vesicle
GO:0031966 mitochondrial membrane
GO:0044754 autolysosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5yis, PDBe:5yis, PDBj:5yis
PDBsum5yis
PubMed29867141
UniProtQ9CQV6|MLP3B_MOUSE Microtubule-associated proteins 1A/1B light chain 3B (Gene Name=Map1lc3b)

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