Structure of PDB 5y6z Chain A Binding Site BS01

Receptor Information

>5y6z Chain A (length=457) Species: 31704 (Coxsackievirus A16)

GEIQWMKSNKETGRLNINGPTRTKLEPSAFYDVFEGSKKPAVLTSKDPRL
EVDFEQALFSKYVGNTLHEPDEYVTQAALHYANQLKQLDINVNKMSMEEA
CYGTEYLEAIDLHTSAGYPYSALGVKKRDILDPITRDTTKMKFYMDKYGL
DLPYSTYVKDELRSLDKIRKGKSRLIEASSLNDSVYLRMTFGHLYETFHA
NPGTVTGSAVGCNPDVFWSKLPILLPGSLFAFDYSGYDASLSPVWFRALE
VVLREIGYPEEAVSLIEGINHTHHVYRNRTYCVLGGMPSGCSGTSIFNSM
INNIIIRTLLIKTFKGIDLDELHMVAYGDDVLASYPFPIDCLELAKTGKE
YGLTMTPCFNEVTWENATFLKRGFLPDHQFPFLIHPTMPMREIHESIRWT
KDARNTQDHVRSLCLLAWHNGKEEYEKFVSTIRSVPIGRALAIPNYENLR
RNWLELF

Ligand information

>5y6z Chain B (length=15)

caggucucucgucga

...............

Receptor-Ligand Complex Structure

Structure summary

• PDB: 5y6z Crystal structure of the coxsackievirus A16 RNA-dependent RNA polymerase elongation complex reveals novel features in motif A dynamics
• Resolution: 2.5 Å
• Binding residue (original residue number in PDB): P20 E108 T114 S115 K127 Y157 K159 I176 A178 R188 H199 G211 C212 N213 S289 G290 C291 Y327 D413 R416 L420
• Binding residue (residue number reindexed from 1): P20 E108 T114 S115 K127 Y157 K159 I176 A178 R188 H199 G211 C212 N213 S289 G290 C291 Y327 D408 R411 L415

Enzymatic activity

• Enzyme Commision number: 2.7.7.48: RNA-directed RNA polymerase.
  3.4.22.28: picornain 3C.
  3.4.22.29: picornain 2A.
  3.6.1.15: nucleoside-triphosphate phosphatase.

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003968 RNA-dependent RNA polymerase activity

Biological Process

• GO:0006351 DNA-templated transcription
• GO:0039694 viral RNA genome replication

External links

• PDB: RCSB:5y6z, PDBe:5y6z, PDBj:5y6z
• PDBsum: 5y6z
• PubMed: 29164396
• UniProt: L7WS61