Structure of PDB 5y3m Chain A Binding Site BS01

Receptor Information
>5y3m Chain A (length=738) Species: 9913 (Bos taurus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LPAFLPCELQPHGQVDCNWLFLKSVPHFSAGAPRANVTSLSLISNRIHHL
HDSDFVHLSNLRVLNLKWNCPPAGLSPMHFPCRMTIEPNTFLAVPTLEEL
NLSYNGITTVPALPSSLVSLSLSHTSILVLGPTHFTGLHALRFLYMDGNC
YYMNPCPRALEVAPGALLGLGNLTHLSLKYNNLTEVPRRLPPSLDTLLLS
YNHIVTLAPEDLANLTALRVLDVGGNCRRCDHARNPCRECPKNFPKLHPD
TFSHLSRLEGLVLKDSSLYKLEKDWFRGLGRLQVLDLSENFLYDYITKTT
IFNDLTQLRRLNLSFNYHKKVSFAHLHLASSFGSLVSLEKLDMHGIFFRS
LTNITLQSLTRLPKLQSLHLQLNFINQAQLSIFGAFPSLLFVDLSDNRIS
GAMPSCNLNFTLDLSRNNLVTIQQEMFTRLSRLQCLRLSHNSISQAVNGS
QFVPLTSLRVLDLSHNKLDLYHGRSFTELPQLEALDLSYNSQPFSMQGVG
HNLSFVAQLPSLRYLSLAHNGIHSRVSQKLSSASLRALDFSGNSLSQMWA
EGDLYLCFFKGLRNLVQLDLSENHLHTLLPRHLDNLPKSLRQLRLRDNNL
AFFNWSSLTVLPRLEALDLAGNQLKALSNGSLPPGIRLQKLDVSSNSIGF
VIPGFFVRATRLIELNLSANALKTVDPSWFGSLAGTLKILDVSANPLHCA
CGAAFVDFLLERQEAVPGLSRRVTCGSPGQLQGRSIFT
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB5y3m Toll-like Receptor 9 Contains Two DNA Binding Sites that Function Cooperatively to Promote Receptor Dimerization and Activation
Resolution2.5 Å
Binding residue
(original residue number in PDB)		D258 Y344 H345 K347 V348 S349 F350 A351 F374 R376 F401
Binding residue
(residue number reindexed from 1)		D231 Y317 H318 K320 V321 S322 F323 A324 F347 R349 F374
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0004888 transmembrane signaling receptor activity
Biological Process
GO:0002224 toll-like receptor signaling pathway
GO:0006955 immune response
Cellular Component
GO:0016020 membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:5y3m, PDBe:5y3m, PDBj:5y3m
PDBsum5y3m
PubMed29625894
UniProtQ5I2M5|TLR9_BOVIN Toll-like receptor 9 (Gene Name=TLR9)

[Back to BioLiP]