Structure of PDB 5xzg Chain A Binding Site BS01
Receptor Information
>5xzg Chain A (length=357) Species:
10090
(Mus musculus) [
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KLKKVLDKLRLKRKDISEAAETVNKVVERLLRRMQKRESEFKGVEQLNTG
SYYEHVKISAPNEFDVMFKLEVPRIELQEYYETGAFYLVKFKRIPRGNPL
SHFLEGEVLSATKMLSKFRKIIKEEVKEIKDIDVSVEKEKPGSPAVTLLI
RNPEEISVDIILALESKGSWPISTKEGLPIQGWLGTKVRTNLRREPFYLV
PKNAKDGNSFQGETWRLSFSHTEKYILNNHGIEKTCCESSGAKCCRKECL
KLMKYLLEQLKKEFQELDAFCSYHVKTAIFHMWTQDPQDSQWDPRNLSSC
FDKLLAFFLECLRTEKLDHYFIPKFNLFSQELIDRKSKEFLSKKIEYERN
NGFPIFD
Ligand information
>5xzg Chain E (length=15) [
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aaattgccgaagacg
Receptor-Ligand Complex Structure
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PDB
5xzg
Small molecule inhibition of cGAS reduces interferon expression in primary macrophages from autoimmune mice.
Resolution
1.828 Å
Binding residue
(original residue number in PDB)
R158 L159 K160 R161 H203 E386 K395
Binding residue
(residue number reindexed from 1)
R10 L11 K12 R13 H55 E238 K247
Enzymatic activity
Enzyme Commision number
2.7.7.86
: cyclic GMP-AMP synthase.
External links
PDB
RCSB:5xzg
,
PDBe:5xzg
,
PDBj:5xzg
PDBsum
5xzg
PubMed
28963528
UniProt
Q8C6L5
|CGAS_MOUSE Cyclic GMP-AMP synthase (Gene Name=Cgas)
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