Structure of PDB 5xze Chain A Binding Site BS01
Receptor Information
>5xze Chain A (length=357) Species:
10090
(Mus musculus) [
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KLKKVLDKLRLKRKDISEAAETVNKVVERLLRRMQKRESEFKGVEQLNTG
SYYEHVKISAPNEFDVMFKLEVPRIELQEYYETGAFYLVKFKRIPRGNPL
SHFLEGEVLSATKMLSKFRKIIKEEVKEIKDIDVSVEKEKPGSPAVTLLI
RNPEEISVDIILALESKGSWPISTKEGLPIQGWLGTKVRTNLRREPFYLV
PKNAKDGNSFQGETWRLSFSHTEKYILNNHGIEKTCCESSGAKCCRKECL
KLMKYLLEQLKKEFQELDAFCSYHVKTAIFHMWTQDPQDSQWDPRNLSSC
FDKLLAFFLECLRTEKLDHYFIPKFNLFSQELIDRKSKEFLSKKIEYERN
NGFPIFD
Ligand information
>5xze Chain E (length=15) [
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aaattgccgaagacg
Receptor-Ligand Complex Structure
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PDB
5xze
Small molecule inhibition of cGAS reduces interferon expression in primary macrophages from autoimmune mice.
Resolution
2.177 Å
Binding residue
(original residue number in PDB)
R158 L159 K160 R161 H203 N376 E386 K395
Binding residue
(residue number reindexed from 1)
R10 L11 K12 R13 H55 N228 E238 K247
Enzymatic activity
Enzyme Commision number
2.7.7.86
: cyclic GMP-AMP synthase.
External links
PDB
RCSB:5xze
,
PDBe:5xze
,
PDBj:5xze
PDBsum
5xze
PubMed
28963528
UniProt
Q8C6L5
|CGAS_MOUSE Cyclic GMP-AMP synthase (Gene Name=Cgas)
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