Structure of PDB 5xxu Chain A Binding Site BS01

Receptor Information
>5xxu Chain A (length=198) Species: 5811 (Toxoplasma gondii) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QEDSIAKMLICKAHIGTKNVEHKMRPYVFKSTSEGIHLINLAKTWEKILM
AARVIVAIENPADVLVISARPYGSRAVLKFSQYVGAQAIAGRWTPGMLTN
QITQKFMEPRLLIVTDPRTDAQAVRESAYANVPVIALCDTDSPLEHVDIC
IPCNNKGKESIALMYWLLAREVLYLRGELPSRSVPWDVMVDMFLWRDP
Ligand information
>5xxu Chain 2 (length=1619) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
aaccugguugauccugccaguagucauaugcuugucuuaaagauuaagcc
augcaugucuaaguauaagcuuuuauacggcuaaacugcgaauggcucau
uaaaacaguuauaguuuauuugauggucuacauggauaaccgugguaauu
cuauggcuaauaccugcgcacaguguuuauuagauacagaaccaagguga
uucauaguaaccgaacggaucgcgcugcgacggaucauucaaguuucuga
ccuaucagcuuucgacgguacuguaauggacuaccguggcagugacgggu
aacggggaauuaggguucgauuccggagagggagccugagaaacggcuac
cacaucuaaggaaggcagcaggcgcgcaaauuacccaauccugauucagg
gagguagugacaagaaauaacaaccuggagugauuggaugauaggaaucc
aaaccccuuucagaguaacaauuggagggcaagucuggugccagcagccg
cgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaag
cucguaguuggauuucugcuggaaggccaauucuagcauccuucuggacu
uuuacuuugagaaaauuagaguguuucaagcaggcuugucgccuugaaua
cucagcauggaauaauaagauuucggcccuauuuugguuucuaggacuga
aguaaugauuaauagggacgguugggggcauucguauuuaacugucagag
gugaaauucuuagauuuguuaaagacgaacuacugcgaaagcauuugcca
aagauguuuucauuaaucaagaacgaaaguuaggggcucgaagacgauca
gauaccgucguagucuuaaccauaaacuaugccgacuagagauaggaaaa
cgucaugacuucuccugcaccuuaugagaaaccaaagucuuuggguucug
gggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggca
ccaccaggcguggagccugcggcuuaauuugacucaacacggggaaacuc
accagguccagacauaggaauugacagauugauagcucuuucuugauucu
augggugguggugcauggccguucuuaguugguggagugauuugucuggu
uaauuccguuaacgaacgagaccuuaaccugcuaaauaggaucaggaacu
ucguguucuuguaucacuucuuagagggacuuugcgugucuaacgcaagg
aaguuugaggcaauaacaggucugugaugcccuuagauguucugggcugc
acgcgcgcuacacugaugcauccaacgaguccuuggccgauaggucuagg
uaaucuugugaguaugcaucgugauggggauagauuauugcaauuauuaa
ucuucaacgaggaaugccuaguaggcgcaagucagcacguugcgccgauu
acgucccugcccuuuguacacaccgcccgucgcuccuaccgauugagugu
uccggugaauuauucggaccguuuuguggcccgaaaugggaaguuuugug
aaccuuaacacuuagaggaaggagaagucguaacaagguuuccguaggug
aaccugcggaaggaucauu
...<<<<<.{.[[[[>>>>><<<..<<<<<<...<<<<..<......<<<
.<<<..<<....<<....<<<.......>>>...>>.>>......<<..<
.....<<<..<<..<<....<<<<.........<.....<<<<<<.....
>>>>>>......>.........<<..<<<<<<.......(((((......
....>>>>>>....>>...<<<<...>>>>...>>>>...>>>>..>>>.
<<<....<<<....<<<<<<...........>>>>>>>>>......>>>.
..<<<.<<<<....>>>>....>>>>>>.<<.<<<..........>>>.>
>.<.<<....>>.>...>>>>>>.........<<<....<<<.....>>>
..>>>..>...>>>>.....<<<.<....>...>>>.....<.<<<....
.......>>>.>.........<<<<<((....<.<<<<.....<<..))>
>.......>>>>>>>>>>..>>>>>>.>>>.........<<<[[.....<
.<<...<<<.<<.....<<<<<<<......>>>>>>>.....<...>...
.<<<<<.<<.......<<...<.......>..<<<.....>>>.....>>
.....>>.>>..>>>.....<<<<<<.<<<....)))))...>>>.>>>>
>>......>>....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<
......>>>......>.>>>>>.>.>>.......<<....>>...>>>>.
..>>>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<..
...>.>>>>...>>>>>>>>..........<<<.<<.<<.<.<<<<<.<<
.<<<..>>>>>.>>>>>..>>>...<...]].>...>>.....>>>.>>>
.<<<......<<<<....>>>>....>>>..]]]].}<<<<<.<<<<<<<
..<<.<<<<<<..<<<.<<<<<<......<<........>>.........
.<<<<<.<....<<<<<......<..<<........>>..>.......>>
>>>...<<.<<<..<<.<<<<<<....<<<.<<<<......>>...<<<.
.....>>>...>>.>>>....<<<<<.<<..<<<<..<<....<<<<<<.
....>>>>>>......>>..>>>>.>>....<<<<<<.....>>>>>.>.
.....>>>>>....>>>.>>>.....>>>>>>>.....>.>>>>>...>>
.>>>>.>>>.....<<<<<<<......<<.<<<.<<<<....>>>>.>>>
....>>.......>>>>>>>...........<<<<<<..........>>>
>>>..........>>>>>>....<<<<<<<.........>>>>>>>....
..>>...>>>>>>>>>>.>>....<..<<.<.<<<<<.<<....<<<<<<
<..<<<..<<.<..<...<<<<<<<<.....>>>>>>>>...>..>.>>.
.>>>..>>>>>>>...>>.>>>>>..>.>>...>.....<<<<<<<<<<.
.>>>>>>>>>>........
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5xxu Cryo-EM structures of the 80S ribosomes from human parasites Trichomonas vaginalis and Toxoplasma gondii
Resolution3.35 Å
Binding residue
(original residue number in PDB)		H33 R103 P106 T110 N111 I113 T114 Q133 E137 Y140
Binding residue
(residue number reindexed from 1)		H22 R92 P95 T99 N100 I102 T103 Q122 E126 Y129
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
Biological Process
GO:0000028 ribosomal small subunit assembly
GO:0002181 cytoplasmic translation
GO:0006412 translation
Cellular Component
GO:0005737 cytoplasm
GO:0005840 ribosome
GO:0015935 small ribosomal subunit
GO:0022627 cytosolic small ribosomal subunit
GO:0030686 90S preribosome
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:5xxu, PDBe:5xxu, PDBj:5xxu
PDBsum5xxu
PubMed28809395
UniProtQ8MPF7|RSSA_TOXGO Small ribosomal subunit protein uS2

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