BioLiP

Receptor Information

>5xwk Chain A (length=530) Species: 28214 (Sphingomonas sp.) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

AARSIAATPPKLIVAISVDQFSADLFSEYRQYYTGGLKRLTSEGAVFPRG
YQSHAATETCPGHSTILTGSRPSRTGIIANNWFDLDAKREDKNLYCAEDE
SQPGSSSDKYEASPLHLKVPTLGGRMKAANPATRVVSVAGKDRAAIMMGG
ATADQVWWLGGPQGYVSYKGVAPTPLVTQVNQAFAQRLAQPNPGFELPAQ
CVSKDFPVQAGNRTVGTGRFARDAGDYKGFRISPEQDAMTLAFAAAAIEN
MQLGKQAQTDIISIGLSATDYVGHTFGTEGTESCIQVDRLDTELGAFFDK
LDKDGIDYVVVLTADHGGHDLPERHRMNAMPMEQRVDMALTPKALNATIA
EKAGLPGKKVIWSDGPSGDIYYDKGLTAAQRARVETEALKYLRAHPQVQT
VFTKAEIAATPSPSGPPESWSLIQEARASFYPSRSGDLLLLLKPRVMSIP
EQAVMGSVATHGSPWDTDRRVPILFWRKGMQHFEQPLGVETVDILPSLAA
LIKLPVPKDQIDGRCLDLVAGKDDSCAGQL

Ligand ID

InChI

InChI=1S/Zn/q+2

InChIKey

PTFCDOFLOPIGGS-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Zn++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Zn+2]

Formula

Name

ZINC ION

PDB chain

5xwk Chain A Residue 602 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	5xwk Crystal Structure of SPAP, an alkaline phosphatase from Sphingomonas in complex with
Resolution	1.901 Å
Binding residue (original residue number in PDB)	D49 T89 D345 H346
Binding residue (residue number reindexed from 1)	D19 T59 D315 H316
Annotation score	1

Enzyme Commision number

3.1.3.1: alkaline phosphatase.

	Molecular Function
GO:0004035	alkaline phosphatase activity

PDB	RCSB:5xwk, PDBe:5xwk, PDBj:5xwk
PDBsum	5xwk
PubMed
UniProt	A1YYW7\|ALPH_SPHSX Alkaline phosphatase PhoK (Gene Name=phoK)

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Structure of PDB 5xwk Chain A Binding Site BS01