Structure of PDB 5xw5 Chain A Binding Site BS01

Receptor Information
>5xw5 Chain A (length=362) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IPTTENLRRSVYLDNTIEFLRGRVYLGAYDYTPEDTDELVFFTVEDAIFY
NSFHLDFGPMNIGHLYRFAVIFHEILNDPENANKAVVFYSSASTRQRANA
ACMLCCYMILVQAWTPHQVLQPLAQVDPPFMPFRDAGYSNADFEITIQDV
VYGVWRAKEKGLIDLHSFNLESYEKYEHVEFGDFNVLTPDFIAFASPQED
LNQPFKSVLNFFANNNVQLVVRLNSHLYNKKHFEDIGIQHLDLIFEDGTC
PDLSIVKNFVGAAETIIKRGGKIAVHSKAGLGRTGCLIGAHLIYTYGFTA
NECIGFLRFIRPGMVVGPQQHWLYLHQNDFREWKYTTRISLKPSEAIGGL
YPLISLEEYRLQ
Ligand information
>5xw5 Chain C (length=8) Species: 559292 (Saccharomyces cerevisiae S288C) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ELGSPLKK
Receptor-Ligand Complex Structure
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PDB5xw5 Structure and dimerization of the catalytic domain of the protein phosphatase Cdc14p, a key regulator of mitotic exit in Saccharomyces cerevisiae
Resolution1.85 Å
Binding residue
(original residue number in PDB)		F47 A130 Y132 E171 D177 D253 S283 K284 A285 L287 G288 R289
Binding residue
(residue number reindexed from 1)		F53 A136 Y138 E177 D183 D247 S277 K278 A279 L281 G282 R283
Enzymatic activity
Enzyme Commision number 3.1.3.48: protein-tyrosine-phosphatase.
Gene Ontology
Biological Process
GO:0006470 protein dephosphorylation
GO:0016311 dephosphorylation

View graph for
Biological Process
External links
PDB RCSB:5xw5, PDBe:5xw5, PDBj:5xw5
PDBsum5xw5
PubMed28758351
UniProtQ00684|CDC14_YEAST Tyrosine-protein phosphatase CDC14 (Gene Name=CDC14)

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