Structure of PDB 5xus Chain A Binding Site BS01 |
| >5xus Chain A (length=1206) Species: 1410628 (Lachnospiraceae bacterium ND2006)
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HMSKLEKFTNCYSLSKTLRFKAIPVGKTQENIDNKRLLVEDEKRAEDYKG
VKKLLDRYYLSFINDVLHSIKLKNLNNYISLFRKKTRTEKENKELENLEI
NLRKEIAKAFKGNEGYKSLFKKDIIETILPEFLDDKDEIALVNSFNGFTT
AFTGFFDNRENMFSEEAKSTSIAFRCINENLTRYISNMDIFEKVDAIFDK
HEVQEIKEKILNSDYDVEDFFEGEFFNFVLTQEGIDVYNAIIGGFVTESG
EKIKGLNEYINLYNQKTKQKLPKFKPLYKQVLSDRESLSFYGEGYTSDEE
VLEVFRNTLNKNSEIFSSIKKLEKLFKNFDEYSSAGIFVKNGPAISTISK
DIFGEWNVIRDKWNAEYDDIHLVTEKYEDDRRKSFKKIGSFSLEQLQEYA
DADLSVVEKLKEIIIQKVDEIYKVYGSSEKLFDADFVLEKSLKKNDAVVA
IMKDLLDSVKSFENYIKAFFGEGKETNRDESFYGDFVLAYDILLKVDHIY
DAIRNYVTQKPYSKDKFKLYFQNPQFMGGWDKDKETDYRATILRYGSKYY
LAIMDKKYAKCLQKIDKDDVNGNYEKINYKLLPGPNKMLPKVFFSKKWMA
YYNPSEDIQKIYKNGTFKKGDMFNLNDCHKLIDFFKDSISRYPKWSNAYD
FNFSETEKYKDIAGFYREVEEQGYKVSFESASKKEVDKLVEEGKLYMFQI
YNKDFSDKSHGTPNLHTMYFKLLFDENNHGQIRLSGGAELFMRRASLKKE
ELVVHPANSPIANKNPDNPKKTTTLSYDVYKDKRFSEDQYELHIPIAINK
CPKNIFKINTEVRVLLKHDDNPYVIGIDRGERNLLYIVVVDGKGNIVEQY
SLNEIINNFNGIRIKTDYHSLLDKKEKERFEARQNWTSIENIKELKAGYI
SQVVHKICELVEKYDAVIALEDLNVKVEKQVYQKFEKMLIDKLNYMVDKK
SNPCATGGALKGYQITNKFESFKSMSTQNGFIFYIPAWLTSKIDPSTGFV
NLLKTKYTSIADSKKFISSFDRIMYVPEEDLFEFALDYKNFSRTDADYIK
KWKLYSYGNRIRIFDWEEVCLTSAYKELFNKYGINYQQGDIRALLCEQSD
KAFYSSFMALMSLMLQMRNSITGRTDVDFLISPVKNSDGIFYDSRNYEAQ
ENAILPKNADANGAYNIARKVLWAIGQFKKAEDEKLDKVKIAISNKEWLE
YAQTSV |
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| PDB | 5xus Structural Basis for the Canonical and Non-canonical PAM Recognition by CRISPR-Cpf1. |
| Resolution | 2.5 Å |
Binding residue
(original residue number in PDB) | S14 K15 T16 R18 F19 K20 K51 N157 R158 R174 K253 L261 Q264 Y277 K278 V280 W355 R386 K390 K464 D505 R508 K520 N706 K707 S710 K712 H714 G715 T716 N718 H720 E743 R747 H759 I765 A766 N767 K768 N769 N772 K774 T777 Y781 Y784 K785 D786 R788 F789 Q793 H797 F863 N864 I868 T870 Y872 R887 E898 G902 S905 H909 V938 K953 K960 |
Binding residue
(residue number reindexed from 1) | S15 K16 T17 R19 F20 K21 K52 N158 R159 R175 K254 L262 Q265 Y278 K279 V281 W356 R382 K386 K460 D501 R504 K516 N702 K703 S706 K708 H710 G711 T712 N714 H716 E739 R743 H755 I761 A762 N763 K764 N765 N768 K770 T773 Y777 Y780 K781 D782 R784 F785 Q789 H793 F859 N860 I864 T866 Y868 R883 E894 G898 S901 H905 V927 K942 K949 |
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