Structure of PDB 5xrn Chain A Binding Site BS01

Receptor Information
>5xrn Chain A (length=141) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SLLPVPYTEAASLSTGSTVTIKGRPLACFLNEPYLQVDFHTEMKEESDIV
FHFQVCFGRRVVMNSREYGAWAQQVESKNMPFQDGQEFELSISVLPDKYQ
VMVNGQSSYTFDHRIKPEAVKMVQVWRDISLTKFNVSYLKR
Ligand information
Ligand IDGOL
InChIInChI=1S/C3H8O3/c4-1-3(6)2-5/h3-6H,1-2H2
InChIKeyPEDCQBHIVMGVHV-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.7.0C(C(CO)O)O
ACDLabs 12.01
CACTVS 3.370		OCC(O)CO
FormulaC3 H8 O3
NameGLYCEROL;
GLYCERIN;
PROPANE-1,2,3-TRIOL
ChEMBLCHEMBL692
DrugBankDB09462
ZINCZINC000000895048
PDB chain5xrn Chain A Residue 201 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5xrn Galectin-10: a new structural type of prototype galectin dimer and effects on saccharide ligand binding.
Resolution1.6 Å
Binding residue
(original residue number in PDB)		H53 V63 N65 Q75
Binding residue
(residue number reindexed from 1)		H52 V62 N64 Q74
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0004622 lysophospholipase activity
GO:0005515 protein binding
GO:0030246 carbohydrate binding
GO:0042802 identical protein binding
GO:0097153 cysteine-type endopeptidase activity involved in apoptotic process
Biological Process
GO:0002667 regulation of T cell anergy
GO:0002724 regulation of T cell cytokine production
GO:0046006 regulation of activated T cell proliferation
GO:0070231 T cell apoptotic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0062023 collagen-containing extracellular matrix

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5xrn, PDBe:5xrn, PDBj:5xrn
PDBsum5xrn
PubMed29293962
UniProtQ05315|LEG10_HUMAN Galectin-10 (Gene Name=CLC)

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