Structure of PDB 5xrk Chain A Binding Site BS01

Receptor Information
>5xrk Chain A (length=141) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SLLPVPYTEAASLSTGSTVTIKGRPLACFLNEPYLQVDFHTEMKEESDIV
FHFQVAFGRRVVMNSREYGAWKQQVESKNMPFQDGQEFELSISVLPDKYQ
VMVNGQSSYTFDHRIKPEAVKMVQVWRDISLTKFNVSYLKR
Ligand information
Ligand IDGOL
InChIInChI=1S/C3H8O3/c4-1-3(6)2-5/h3-6H,1-2H2
InChIKeyPEDCQBHIVMGVHV-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.7.0C(C(CO)O)O
ACDLabs 12.01
CACTVS 3.370		OCC(O)CO
FormulaC3 H8 O3
NameGLYCEROL;
GLYCERIN;
PROPANE-1,2,3-TRIOL
ChEMBLCHEMBL692
DrugBankDB09462
ZINCZINC000000895048
PDB chain5xrk Chain A Residue 201 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5xrk Galectin-10: a new structural type of prototype galectin dimer and effects on saccharide ligand binding.
Resolution1.7 Å
Binding residue
(original residue number in PDB)		H53 V63 N65 W72 Q75
Binding residue
(residue number reindexed from 1)		H52 V62 N64 W71 Q74
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0004622 lysophospholipase activity
GO:0005515 protein binding
GO:0030246 carbohydrate binding
GO:0042802 identical protein binding
GO:0097153 cysteine-type endopeptidase activity involved in apoptotic process
Biological Process
GO:0002667 regulation of T cell anergy
GO:0002724 regulation of T cell cytokine production
GO:0046006 regulation of activated T cell proliferation
GO:0070231 T cell apoptotic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0062023 collagen-containing extracellular matrix

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5xrk, PDBe:5xrk, PDBj:5xrk
PDBsum5xrk
PubMed29293962
UniProtQ05315|LEG10_HUMAN Galectin-10 (Gene Name=CLC)

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