Structure of PDB 5xou Chain A Binding Site BS01

Receptor Information
>5xou Chain A (length=564) Species: 262724 (Thermus thermophilus HB27) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LGKTEVFLNRFALRPLNPEELRPWRLEVVLDPPPGREEVYPLLAQVARRA
GGVTVRMGDGLASWSPPEVLVLEGTLARMGQTYAYRLYPKGRRPLDPKDP
GERSVLSALARRLLQERLRRLEGVWVEGLAVYRREVLGGAVLDLWVSDSG
AFLLEVDPALPWEERRRRTREIASWIGRRLGLGTPEAVRAQAYRLSIPKL
MGRRAVSKPADALRVGFYRAQETALALLRLDGAQGWPEFLRRALLRAFGA
SGASLRLHTLHAHPSQGLAFREALRKAKEEGVQAVLVLTPPMAWEDRNRL
KALLLREGLPSQILNVPLREEERHRWENALLGLLAKAGLQVVALSGAYPA
ELAVGFDAGGRESFRFGGAACAVGGDGGHLLWTLPEAQAGERIPQEVVWD
LLEETLWAFRRKAGRLPSRVLLLRNGRVPQDEFALALEALAREGIAYDLV
SVRKSGGGRVYPVQGRLADGLYVPLEDKTFLLLTVHRDFRGTPRPLKLVH
EAGDTPLEALAHQIFHLTRLYPASGFAFPRLPAPLHLADRLVKEVGRLGI
RHLKEVDREKLFFV
Ligand information
Receptor-Ligand Complex Structure
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PDB5xou Structure/cleavage-based insights into helical perturbations at bulge sites within T. thermophilus Argonaute silencing complexes
Resolution2.63 Å
Binding residue
(original residue number in PDB)		Y43 A170 R286 M413 W415 K422 Q433 I434 L435 N436 R446 N449 R486 E512 R513 P550 Q551 R580 R611 T613 P614 R615 A644 P650 R651 H657 R661 V685
Binding residue
(residue number reindexed from 1)		Y40 A159 R165 M292 W294 K301 Q312 I313 L314 N315 R325 N328 R365 E391 R392 P429 Q430 R459 R490 T492 P493 R494 A523 P529 R530 H536 R540 V564
Enzymatic activity
Enzyme Commision number 3.1.24.-
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0004519 endonuclease activity
GO:0004520 DNA endonuclease activity
GO:0030145 manganese ion binding
GO:0046872 metal ion binding
Biological Process
GO:0006260 DNA replication
GO:0044355 clearance of foreign intracellular DNA

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Molecular Function
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Biological Process
External links
PDB RCSB:5xou, PDBe:5xou, PDBj:5xou
PDBsum5xou
PubMed28911094
UniProtQ746M7|AGO_THET2 Protein argonaute (Gene Name=ago)

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