Structure of PDB 5xn1 Chain A Binding Site BS01 |
| >5xn1 Chain A (length=551) Species: 11676 (Human immunodeficiency virus 1)
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SPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGP
ENPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKQ
KKSVTVLDVGDAYFSVPLDKDFRKYTAFTIPSINNETPGIRYQYNVLPMG
WKGSPAIFQSSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLEIGQHRTKI
EELRQHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSW
TVNDIQKLVGKLNWASQIYAGIKVRQLSKLLRGTKALTEVVPLTEEAELE
LAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTG
KYARMKGAHTNDVKQLTEAVQKIATESIVIWGKTPKFKLPIQKETWEAWW
TEYWQATWIPEWEFVNTPPLVKLWYQLEKEPIIGAETFYVDGAANRETKL
GKAGYVTDRGRQKVVPLTDTTNQKTELQAIHLALQDSGLEVNIVTDSQYA
LGIIQAQPDKSESELVSQIIEQLIKKEKVYLAWVPAHKGIGGNEQVDKLV
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| PDB | 5xn1 HIV-1 with HBV-associated Q151M substitution in RT becomes highly susceptible to entecavir: structural insights into HBV-RT inhibition by entecavir. |
| Resolution | 2.446 Å |
Binding residue
(original residue number in PDB) | W24 F61 L74 D76 R78 E89 I94 G152 K154 P157 Y183 M230 G231 N255 Q258 K259 G262 K263 W266 S280 R284 G285 K353 H361 K374 R448 T473 Q475 Y501 |
Binding residue
(residue number reindexed from 1) | W22 F59 L72 D74 R76 E87 I92 G150 K152 P155 Y181 M228 G229 N253 Q256 K257 G260 K261 W264 S278 R282 G283 K351 H359 K372 R446 T471 Q473 Y499 |
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