Structure of PDB 5xc6 Chain A Binding Site BS01

Receptor Information
>5xc6 Chain A (length=451) Species: 11070 (dengue virus type 4) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GSAMGEPDYEVDEDIFRKKRLTIMDLHPGAGKTKRILPSIVREALKRRLR
TLILAPTRVVAAEMEEALRGLPIRYQTPAVKSDHTGREIVDLMCHATFTT
RLLSSTRVPNYNLIVMDEAHFTDPCSVAARGYISTRVEMGEAAAIFMTAT
PPGSIDPFPQSNSPIEDIEREIPERSWNTGFDWITDYQGKTVWFVPSIKA
GNDIANCLRKSGKRVIQLSRKTFDTEYPKTKLTDWDFVVTTDISEMGANF
RAGRVIDPRRCLKPVILTDGPERVILAGPIPVTPASAAQRRGRIGRNPAQ
EDDQYVFSGDPLKNDEDHAHWTEAKMLLDNIYTPEGIIPTLFGPEREKTQ
AIDGEFRLRGEQRKTFVELMRRGDLPVWLSYKVASAGISYKDREWCFTGE
RNNQILEENMEVEIWTREGEKKKLRPKWLDARVYADPMALKDFKEFASGR
K
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5xc6 NS3 helicase from dengue virus specifically recognizes viral RNA sequence to ensure optimal replication
Resolution2.9 Å
Binding residue
(original residue number in PDB)		T224 R225 T244 P245 C261 A263 T264 I365 S386 R387 T408 D409 I410 P431 L443 R538 R599 D603
Binding residue
(residue number reindexed from 1)		T57 R58 T77 P78 C94 A96 T97 I198 S219 R220 T241 D242 I243 P264 L276 R371 R432 D436
Enzymatic activity
Enzyme Commision number 3.4.21.91: flavivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0004386 helicase activity
GO:0005524 ATP binding

View graph for
Molecular Function
External links
PDB RCSB:5xc6, PDBe:5xc6, PDBj:5xc6
PDBsum5xc6
PubMed29165589
UniProtM9P7S0

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