Structure of PDB 5x94 Chain A Binding Site BS01
Receptor Information
>5x94 Chain A (length=206) Species:
9606
(Homo sapiens) [
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RRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTH
IKIQNTGDYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLN
CADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRT
GSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLK
QPLNTT
Ligand information
>5x94 Chain L (length=9) Species:
102608
(Helicobacter pylori F32) [
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PIYATIDFD
Receptor-Ligand Complex Structure
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PDB
5x94
Differential Mechanisms for SHP2 Binding and Activation Are Exploited by Geographically Distinct Helicobacter pylori CagA Oncoproteins.
Resolution
2.6 Å
Binding residue
(original residue number in PDB)
E17 R32 S34 S36 T42 T52 H53 I54 K55 G67 G68 K89 E90
Binding residue
(residue number reindexed from 1)
E14 R29 S31 S33 T39 T49 H50 I51 K52 G64 G65 K86 E87
Enzymatic activity
Enzyme Commision number
3.1.3.48
: protein-tyrosine-phosphatase.
External links
PDB
RCSB:5x94
,
PDBe:5x94
,
PDBj:5x94
PDBsum
5x94
PubMed
28930683
UniProt
Q06124
|PTN11_HUMAN Tyrosine-protein phosphatase non-receptor type 11 (Gene Name=PTPN11)
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