Structure of PDB 5x8n Chain A Binding Site BS01

Receptor Information
>5x8n Chain A (length=425) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TVNWSVEDIVKGINSNNLESQLQATQAARKLLSREKQPPIDNIIRAGLIP
KFVSFLGKTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLA
SPHAHISEQAVWALGNIAGDGSAFRDLVIKHGAIDPLLALLAVPDLSTLA
CGYLRNLTWTLSNLCRNKNPAPPLDAVEQILPTLVRLLHHNDPEVLADSC
WAISYLTDGPNERIEMVVKKGVVPQLVKLLGATELPIVTPALRAIGNIVT
GTDEQTQKVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQ
VVNHGLVPFLVGVLSKADFKTQKEAAWAITNYTSGGTVEQIVYLVHCGII
EPLMNLLSAKDTKIIQVILDAISNIFQAAEKLGETEKLSIMIEECGGLDK
IEALQRHENESVYKASLNLIEKYFS
Ligand information
>5x8n Chain B (length=8) Species: 10377 (Human herpesvirus 4 strain B95-8) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
PRRVRRRV
Receptor-Ligand Complex Structure
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PDB5x8n Crystal structure of importin-alpha bound to the nuclear localization signal of Epstein-Barr virus EBNA-LP protein
Resolution2.15 Å
Binding residue
(original residue number in PDB)		L104 S105 R106 P110 W142 N146 S149 G150 T151 S152 Q181 W184 N188 G191 D192 N228 W231 S234 N235 R238 Y277
Binding residue
(residue number reindexed from 1)		L32 S33 R34 P38 W70 N74 S77 G78 T79 S80 Q109 W112 N116 G119 D120 N156 W159 S162 N163 R166 Y205
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0061608 nuclear import signal receptor activity
Biological Process
GO:0006606 protein import into nucleus
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5x8n, PDBe:5x8n, PDBj:5x8n
PDBsum5x8n
PubMed28383161
UniProtP52293|IMA1_MOUSE Importin subunit alpha-1 (Gene Name=Kpna2)

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