Structure of PDB 5wuk Chain A Binding Site BS01

Receptor Information
>5wuk Chain A (length=366) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYE
CHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRII
NPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTL
VAIFGGVEGHRDEVLSADYDLLGEKIMSCDMDHSLKLWRINSKRMMNAIK
ESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCE
NAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQK
MLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSIL
IAVCDDASIWRWDRLR
Ligand information
>5wuk Chain B (length=28) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
MFSSNRQKILERTEILNQEWKQRRIQPV
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5wuk Split luciferase-based biosensors for characterizing EED binders
Resolution2.03 Å
Binding residue
(original residue number in PDB)		W103 H104 S105 K106 D109 Y154 S159 P161 P177 I178 R201 L246 L247 L315 G316 D317 L318 K332 M336 F372 W373 Q374 L391 E392 E394 R420
Binding residue
(residue number reindexed from 1)		W28 H29 S30 K31 D34 Y79 S84 P86 P102 I103 R126 L171 L172 L240 G241 D242 L243 K257 M261 F297 W298 Q299 L316 E317 E319 R345
Enzymatic activity
Enzyme Commision number ?
External links
PDB RCSB:5wuk, PDBe:5wuk, PDBj:5wuk
PDBsum5wuk
PubMed28111304
UniProtO75530|EED_HUMAN Polycomb protein EED (Gene Name=EED)

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