Structure of PDB 5wrm Chain A Binding Site BS01

Receptor Information
>5wrm Chain A (length=259) Species: 10116 (Rattus norvegicus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IGWRREGIKYRRNELFLDVLESVNLLMSPQGQVLSAHVSGRVVMKSYLSG
MPECKFGMNDKKQSIAIDDCTFHQCVRLSKFDSERSISFIPPDGEFELMR
YRTTKDIILPFRVIPLVREVGRTKLEVKVVIKSNFKPSLLAQKIEVRIPT
PLNTSGVQVICMKGKAKYKASENAIVWKIKRMAGMKESQISAEIELLPTN
DKKKWARPPISMNFEVPFAPSGLKVRYLKVFEPKLNYSDHDVIKWVRYIG
RSGIYETRC
Ligand information
Receptor-Ligand Complex Structure
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PDB5wrm IRS-1 acts as an endocytic regulator of IGF-I receptor to facilitate sustained IGF signaling
Resolution2.597 Å
Binding residue
(original residue number in PDB)		F174 D176 K420 W421 V422 R423
Binding residue
(residue number reindexed from 1)		F16 D18 K244 W245 V246 R247
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Biological Process
GO:0006886 intracellular protein transport
GO:0016192 vesicle-mediated transport
Cellular Component
GO:0030131 clathrin adaptor complex

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Biological Process
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Cellular Component
External links
PDB RCSB:5wrm, PDBe:5wrm, PDBj:5wrm
PDBsum5wrm
PubMed29661273
UniProtP84092|AP2M1_RAT AP-2 complex subunit mu (Gene Name=Ap2m1)

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